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Chemical Compound Review

AGN-PC-00YJD9     [17-acetyloxy-10,13-dimethyl- 2,16-bis(1...

Synonyms: AC1L1IP7
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Disease relevance of Pavulon


Psychiatry related information on Pavulon


High impact information on Pavulon


Chemical compound and disease context of Pavulon


Biological context of Pavulon


Anatomical context of Pavulon


Associations of Pavulon with other chemical compounds


Gene context of Pavulon

  • The depolarization component that is resistant to alphaCTxGI was antagonized by pancuronium (3-10 microM) and by a 4-oxystilbene derivative (F3, 0.1-0.5 microM) at concentrations considered highly specific for alpha7* nAChRs [29].
  • For sake of comparison the protein binding and the interaction of tubocurarine and pancuronium with AChE and BuChE were observed also [30].
  • We conclude that the use of perioperative TOF monitoring decreases the incidence of pancuronium-induced PORC [31].
  • We investigated the effect of AT1 receptor blockade in the NTS on the response to stimulation of HDA in anaesthetised rats treated with the neuromuscular blocking agent pancuronium bromide [32].
  • The site recognized by B mAbs binds alpha-BuTx with a forward rate constant of 9.3 X 10(5) M-1 s-1, dTC with a KD of (4.6 +/- 0.3) X 10(-6) M, and pancuronium with a KD of (9.3 +/- 0.8) X 10(-6) M [33].

Analytical, diagnostic and therapeutic context of Pavulon


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  2. Hypotension associated with pancuronium use in the newborn. McIntosh, N. Lancet (1985) [Pubmed]
  3. Prolonged weakness after the withdrawal of atracurium. Manthous, C.A., Chatila, W. Am. J. Respir. Crit. Care Med. (1994) [Pubmed]
  4. Complete ophthalmoplegia as a complication of acute corticosteroid- and pancuronium-associated myopathy. Sitwell, L.D., Weinshenker, B.G., Monpetit, V., Reid, D. Neurology (1991) [Pubmed]
  5. Pharmacokinetics of pancuronium in patients undergoing coronary artery surgery with and without low dose dopamine. Wierda, J.M., van der Starre, P.J., Scaf, A.H., Kloppenburg, W.D., Proost, J.H., Agoston, S. Clinical pharmacokinetics. (1990) [Pubmed]
  6. Asphyxia, cardiac arrest and resuscitation in rats. I. Short term recovery. Hendrickx, H.H., Rao, G.R., Safar, P., Gisvold, S.E. Resuscitation. (1984) [Pubmed]
  7. Who--and how--to kill are focus of US death penalty cases. Questions about prisoners' mental competence and use of pancuronium bromide ignite recent controversy. Oransky, I. Lancet (2003) [Pubmed]
  8. Role of the diaphragm in the genesis of lower esophageal sphincter pressure in the cat. Boyle, J.T., Altschuler, S.M., Nixon, T.E., Tuchman, D.N., Pack, A.I., Cohen, S. Gastroenterology (1985) [Pubmed]
  9. Pancuronium during mechanical ventilation speeds recovery of lungs of infants with hyaline membrane disease. Pollitzer, M.J., Reynolds, E.O., Shaw, D.G., Thomas, R.M. Lancet (1981) [Pubmed]
  10. Pancuronium bromide. Roizen, M.F., Feeley, T.W. Ann. Intern. Med. (1978) [Pubmed]
  11. Measurement of lung microvascular pressure in the intact anesthetized rabbit by the micropuncture technique. Bhattacharya, S., Glucksberg, M.R., Bhattacharya, J. Circ. Res. (1989) [Pubmed]
  12. Myotonia, a new inherited muscle disease in mice. Heller, A.H., Eicher, E.M., Hallett, M., Sidman, R.L. J. Neurosci. (1982) [Pubmed]
  13. Adjunctive drug treatment in severe hypoxic respiratory failure. Elsasser, S., Schächinger, H., Strobel, W. Drugs (1999) [Pubmed]
  14. The incidence of myocardial ischemia during anesthesia for coronary artery bypass surgery in patients receiving pancuronium or vecuronium. O'Connor, J.P., Ramsay, J.G., Wynands, J.E., Ralley, F.E., Casey, W.F., Smith, C.E., Robbins, G.R., Bilodeau, J., Sami, M.H. Anesthesiology (1989) [Pubmed]
  15. A comparison of the skeletal neuromuscular and autonomic ganglion-blocking potencies of five non-depolarizing relaxants. Birmingham, A.T., Hussain, S.Z. Br. J. Pharmacol. (1980) [Pubmed]
  16. Mechanism of the bradycardia produced in the cat by the anticholinesterase neostigmine. Backman, S.B., Bachoo, M., Polosa, C. J. Pharmacol. Exp. Ther. (1993) [Pubmed]
  17. The kinetics of competitive antagonism by cisatracurium of embryonic and adult nicotinic acetylcholine receptors. Demazumder, D., Dilger, J.P. Mol. Pharmacol. (2001) [Pubmed]
  18. Heterogeneity of binding sites on cardiac muscarinic receptors induced by the neuromuscular blocking agents gallamine and pancuronium. Dunlap, J., Brown, J.H. Mol. Pharmacol. (1983) [Pubmed]
  19. Kinetic analysis of pancuronium interaction with sodium channels in squid axon membranes. Yeh, J.Z., Narahashi, T. J. Gen. Physiol. (1977) [Pubmed]
  20. Effects of inflation on the coupling between the ribs and the lung in dogs. De Troyer, A., Leduc, D. J. Physiol. (Lond.) (2004) [Pubmed]
  21. Pancuronium improves the neuromuscular transmission defect of human organophosphate intoxication. Besser, R., Vogt, T., Gutmann, L. Neurology (1990) [Pubmed]
  22. Validation of a flow cytometric assay detecting in vitro basophil activation for the diagnosis of muscle relaxant allergy. Abuaf, N., Rajoely, B., Ghazouani, E., Levy, D.A., Pecquet, C., Chabane, H., Leynadier, F. J. Allergy Clin. Immunol. (1999) [Pubmed]
  23. Effects of chronic nicotinic ligand exposure on functional activity of nicotinic acetylcholine receptors expressed by cells of the PC12 rat pheochromocytoma or the TE671/RD human clonal line. Lukas, R.J. J. Neurochem. (1991) [Pubmed]
  24. Potentiation of neuromuscular blockade by verapamil. Durant, N.N., Nguyen, N., Katz, R.L. Anesthesiology (1984) [Pubmed]
  25. Interactions of monovalent cations with sodium channels in squid axon. II. Modification of pharmacological inactivation gating. Yeh, J.Z., Oxford, G.S. J. Gen. Physiol. (1985) [Pubmed]
  26. Neuromuscular blocking drugs do not alter the pupillary light reflex of anesthetized humans. Gray, A.T., Krejci, S.T., Larson, M.D. Arch. Neurol. (1997) [Pubmed]
  27. Effects of apamin, quinine and neuromuscular blockers on calcium-activated potassium channels in guinea-pig hepatocytes. Cook, N.S., Haylett, D.G. J. Physiol. (Lond.) (1985) [Pubmed]
  28. Assessment of cardiac sympathetic regulation by respiratory-related arterial pressure variability in the rat. Yang, C.C., Kuo, T.B. J. Physiol. (Lond.) (1999) [Pubmed]
  29. Mouse muscle denervation increases expression of an alpha7 nicotinic receptor with unusual pharmacology. Tsuneki, H., Salas, R., Dani, J.A. J. Physiol. (Lond.) (2003) [Pubmed]
  30. Protein binding of atracurium and other short-acting neuromuscular blocking agents and their interaction with human cholinesterases. Foldes, F.F., Deery, A. British journal of anaesthesia. (1983) [Pubmed]
  31. Perioperative train-of-four monitoring and residual curarization. Shorten, G.D., Merk, H., Sieber, T. Canadian journal of anaesthesia = Journal canadien d'anesthésie. (1995) [Pubmed]
  32. Angiotensin AT1 receptor antagonist losartan and the defence reaction in the anaesthetised rat. Effect on the carotid chemoreflex. Rocha, I., Brás-Rosário, L., Amparo-Barros, M., Silva-Carvalho, L. Exp. Physiol. (2003) [Pubmed]
  33. Monoclonal antibodies specific for each of the two toxin-binding sites of Torpedo acetylcholine receptor. Dowding, A.J., Hall, Z.W. Biochemistry (1987) [Pubmed]
  34. Pancuronium prevents pneumothoraces in ventilated premature babies who actively expire against positive pressure inflation. Greenough, A., Wood, S., Morley, C.J., Davis, J.A. Lancet (1984) [Pubmed]
  35. Clinical pharmacokinetics of neuromuscular relaxants in pregnancy. Guay, J., Grenier, Y., Varin, F. Clinical pharmacokinetics. (1998) [Pubmed]
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