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Gene Review

Cybrd1  -  cytochrome b reductase 1

Mus musculus

Synonyms: 2210407P13Rik, Cytochrome b reductase 1, Dcytb, Duodenal cytochrome b
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Disease relevance of Cybrd1

  • Intestinal Hcp1 mRNA content was not significantly changed by iron overload (600 mg/kg); however, it was increased to 170 % of controls 72 h after withdrawal of 0.7 ml of blood; the same treatment increased intestinal Cybrd1 mRNA to 900 % of controls [1].

High impact information on Cybrd1

  • Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis [2].
  • This was thought to be mediated by duodenal cytochrome b (Cybrd1), a ferric reductase enzyme resident on the luminal surface of intestinal absorptive cells [3].
  • In parallel, HFE -/- resulted in reduced renal expression of Dcytb and DMT-1 [4].
  • Transcript levels of genes involved in intestinal iron absorption, including Dcytb, DMT1, and ferroportin, are significantly elevated in the absence of hepcidin [5].

Biological context of Cybrd1

  • This change may be linked to inappropriate iron sensing by the liver based on decreased TfR-2 expression, resulting in reduced circulating hepcidin levels and an inappropriate up-regulation of Dcytb and DMT-1 driven iron absorption [4].

Anatomical context of Cybrd1


Other interactions of Cybrd1

  • We examined the expression of the ferric reductase Dcytb, DMT1 and some other genes involved in Fe metabolism in tissues of mice dosed with PHZ [6].


  1. Effect of lipopolysaccharide and bleeding on the expression of intestinal proteins involved in iron and haem transport. Krijt, J., Vokurka, M., Sefc, L., Duricov??, D., Necas, E. Folia Biol. (Praha) (2006) [Pubmed]
  2. Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis. Muckenthaler, M., Roy, C.N., Custodio, A.O., Miñana, B., deGraaf, J., Montross, L.K., Andrews, N.C., Hentze, M.W. Nat. Genet. (2003) [Pubmed]
  3. Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice. Gunshin, H., Starr, C.N., Direnzo, C., Fleming, M.D., Jin, J., Greer, E.L., Sellers, V.M., Galica, S.M., Andrews, N.C. Blood (2005) [Pubmed]
  4. Regulatory networks for the control of body iron homeostasis and their dysregulation in HFE mediated hemochromatosis. Ludwiczek, S., Theurl, I., Bahram, S., Schümann, K., Weiss, G. J. Cell. Physiol. (2005) [Pubmed]
  5. A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Wang, R.H., Li, C., Xu, X., Zheng, Y., Xiao, C., Zerfas, P., Cooperman, S., Eckhaus, M., Rouault, T., Mishra, L., Deng, C.X. Cell metabolism. (2005) [Pubmed]
  6. Tissue-specific changes in iron metabolism genes in mice following phenylhydrazine-induced haemolysis. Latunde-Dada, G.O., Vulpe, C.D., Anderson, G.J., Simpson, R.J., McKie, A.T. Biochim. Biophys. Acta (2004) [Pubmed]
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