Gene Review:
Hfe - hemochromatosis
Mus musculus
Synonyms:
Hereditary hemochromatosis protein homolog, MR2, Mr2
- Contributions of beta2-microglobulin-dependent molecules and lymphocytes to iron regulation: insights from HfeRag1(-/-) and beta2mRag1(-/-) double knock-out mice. Miranda, C.J., Makui, H., Andrews, N.C., Santos, M.M. Blood (2004)
- Uroporphyria caused by ethanol in Hfe(-/-) mice as a model for porphyria cutanea tarda. Sinclair, P.R., Gorman, N., Trask, H.W., Bement, W.J., Szakacs, J.G., Elder, G.H., Balestra, D., Sinclair, J.F., Gerhard, G.S. Hepatology (2003)
- Obesity in BSB mice is correlated with expression of genes for iron homeostasis and leptin. Farahani, P., Chiu, S., Bowlus, C.L., Boffelli, D., Lee, E., Fisler, J.S., Krauss, R.M., Warden, C.H. Obes. Res. (2004)
- Uroporphyria in the uroporphyrinogen decarboxylase-deficient mouse: Interplay with siderosis and polychlorinated biphenyl exposure. Franklin, M.R., Phillips, J.D., Kushner, J.P. Hepatology (2002)
- Expression of stimulator of Fe transport is not enhanced in Hfe knockout mice. Knutson, M.D., Levy, J.E., Andrews, N.C., Wessling-Resnick, M. J. Nutr. (2001)
- Genetic factors influence ethanol-induced uroporphyria in Hfe(-/-) mice. Gorman, N., Trask, H.W., Bement, W.J., Szakacs, J.G., Elder, G.H., Balestra, D., Jacobs, N.J., Jacobs, J.M., Sinclair, J.F., Gerhard, G.S., Sinclair, P.R. Hepatology (2004)
- Regulation of Hfe by stress factors in BV-2 cells. Lee, S.Y., Connor, J.R. Neurobiol. Aging (2005)
- An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice. Roy, C.N., Custodio, A.O., de Graaf, J., Schneider, S., Akpan, I., Montross, L.K., Sanchez, M., Gaudino, A., Hentze, M.W., Andrews, N.C., Muckenthaler, M.U. Nat. Genet. (2004)
- Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis. Muckenthaler, M., Roy, C.N., Custodio, A.O., Miñana, B., deGraaf, J., Montross, L.K., Andrews, N.C., Hentze, M.W. Nat. Genet. (2003)
- Uroporphyria in Hfe mutant mice given 5-aminolevulinate: a new model of Fe-mediated porphyria cutanea tarda. Sinclair, P.R., Gorman, N., Walton, H.S., Bement, W.J., Sinclair, J.F., Gerhard, G.S., Szakacs, J.G., Andrews, N.C., Levy, J.E. Hepatology (2001)
- Iron in skin of mice with three etiologies of systemic iron overload. Adams, B.D., Lazova, R., Andrews, N.C., Milstone, L.M. J. Invest. Dermatol. (2005)
- Distinct requirements for Hfe in basal and induced hepcidin levels in iron overload and inflammation. Constante, M., Jiang, W., Wang, D., Raymond, V.A., Bilodeau, M., Santos, M.M. Am. J. Physiol. Gastrointest. Liver Physiol. (2006)
- Haptoglobin modifies the hemochromatosis phenotype in mice. Tolosano, E., Fagoonee, S., Garuti, C., Valli, L., Andrews, N.C., Altruda, F., Pietrangelo, A. Blood (2005)
- Mouse strain differences determine severity of iron accumulation in Hfe knockout model of hereditary hemochromatosis. Fleming, R.E., Holden, C.C., Tomatsu, S., Waheed, A., Brunt, E.M., Britton, R.S., Bacon, B.R., Roopenian, D.C., Sly, W.S. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Accelerated Transferrin Degradation in HFE-Deficient Mice Is Associated with Increased Transferrin Saturation. Chaudhury, C., Kim, J., Mehnaz, S., Wani, M.A., Oberyszyn, T.M., Bronson, C.L., Mohanty, S., Hayton, W.L., Robinson, J.M., Anderson, C.L. J. Nutr. (2006)
- Nontransferrin-bound iron uptake by hepatocytes is increased in the Hfe knockout mouse model of hereditary hemochromatosis. Chua, A.C., Olynyk, J.K., Leedman, P.J., Trinder, D. Blood (2004)
- A compartmental model of iron regulation in the mouse. Lao, B.J., Kamei, D.T. J. Theor. Biol. (2006)
- Direct recognition by alphabeta cytolytic T cells of Hfe, a MHC class Ib molecule without antigen-presenting function. Rohrlich, P.S., Fazilleau, N., Ginhoux, F., Firat, H., Michel, F., Cochet, M., Laham, N., Roth, M.P., Pascolo, S., Nato, F., Coppin, H., Charneau, P., Danos, O., Acuto, O., Ehrlich, R., Kanellopoulos, J., Lemonnier, F.A. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Increased glucose disposal and AMP-dependent kinase signaling in a mouse model of hemochromatosis. Huang, J., Gabrielsen, J.S., Cooksey, R.C., Luo, B., Boros, L.G., Jones, D.L., Jouihan, H.A., Soesanto, Y., Knecht, L., Hazel, M.W., Kushner, J.P., McClain, D.A. J. Biol. Chem. (2007)
- Iron uptake from plasma transferrin by the duodenum is impaired in the Hfe knockout mouse. Trinder, D., Olynyk, J.K., Sly, W.S., Morgan, E.H. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Expression of the DMT1 (NRAMP2/DCT1) iron transporter in mice with genetic iron overload disorders. Canonne-Hergaux, F., Levy, J.E., Fleming, M.D., Montross, L.K., Andrews, N.C., Gros, P. Blood (2001)
- Iron absorption and hepatic iron uptake are increased in a transferrin receptor 2 (Y245X) mutant mouse model of hemochromatosis type 3. Drake, S.F., Morgan, E.H., Herbison, C.E., Delima, R., Graham, R.M., Chua, A.C., Leedman, P.J., Fleming, R.E., Bacon, B.R., Olynyk, J.K., Trinder, D. Am. J. Physiol. Gastrointest. Liver Physiol. (2007)
- Regulation of transferrin receptor 2 protein levels by transferrin. Robb, A., Wessling-Resnick, M. Blood (2004)
- Hepatic expression of hemochromatosis genes in two mouse strains after phlebotomy and iron overload. Bondi, A., Valentino, P., Daraio, F., Porporato, P., Gramaglia, E., Carturan, S., Gottardi, E., Camaschella, C., Roetto, A. Haematologica (2005)
- Contribution of Hfe expression in macrophages to the regulation of hepatic hepcidin levels and iron loading. Makui, H., Soares, R.J., Jiang, W., Constante, M., Santos, M.M. Blood (2005)
- Iron dysregulation combined with aging prevents sepsis-induced apoptosis. Javadi, P., Buchman, T.G., Stromberg, P.E., Turnbull, I.R., Vyas, D., Hotchkiss, R.S., Karl, I.E., Coopersmith, C.M. J. Surg. Res. (2005)