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Gene Review

Tfr2  -  transferrin receptor 2

Mus musculus

Synonyms: TfR2, Transferrin receptor protein 2, Trfr2
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Disease relevance of Trfr2

  • Targeted disruption of the hepatic transferrin receptor 2 gene in mice leads to iron overload [1].
  • We found decreased expression of hepcidin and TfR2 and increased expression of TfR1 and NGAL in the beta-thalassemia mouse models, compared with the control mice [2].

High impact information on Trfr2

  • To determine the contribution of liver expressed TfR2 in iron homeostasis, we have generated and characterized a liver-specific TfR2-knockout (KO) mouse [1].
  • In situ hybridization demonstrated abundant TfR2 expression in hepatocytes [3].
  • RESULTS: Ferroportin1, transferrin receptor 2 and HAMP mRNA levels displayed no significant strain differences [4].
  • Duodenal Fe absorption and hepatic Fe uptake were measured in vivo by (59)Fe-labeled ascorbate in TfR2 mutant mice, wild-type mice, and Fe-loaded wild-type mice (2% dietary carbonyl Fe) [5].
  • Even when compared with Fe-loaded wild-type mice, TfR2 mutant mice had increased Fe absorption, increased duodenal Fe transport gene expression, increased liver Fe uptake, and decreased liver hepcidin expression [5].

Chemical compound and disease context of Trfr2


Anatomical context of Trfr2


Other interactions of Trfr2


Analytical, diagnostic and therapeutic context of Trfr2

  • Levels of the iron-related proteins TfR1, TfR2, ferritin, and prohepcidin were analyzed by immunoblotting [1].


  1. Targeted disruption of the hepatic transferrin receptor 2 gene in mice leads to iron overload. Wallace, D.F., Summerville, L., Subramaniam, V.N. Gastroenterology (2007) [Pubmed]
  2. mRNA expression of iron regulatory genes in beta-thalassemia intermedia and beta-thalassemia major mouse models. Weizer-Stern, O., Adamsky, K., Amariglio, N., Rachmilewitz, E., Breda, L., Rivella, S., Rechavi, G. Am. J. Hematol. (2006) [Pubmed]
  3. Transferrin receptor 2: continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis. Fleming, R.E., Migas, M.C., Holden, C.C., Waheed, A., Britton, R.S., Tomatsu, S., Bacon, B.R., Sly, W.S. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  4. Different expression pattern of hepcidin genes in the liver and pancreas of C57BL/6N and DBA/2N mice. Krijt, J., Cmejla, R., Sýkora, V., Vokurka, M., Vyoral, D., Necas, E. J. Hepatol. (2004) [Pubmed]
  5. Iron absorption and hepatic iron uptake are increased in a transferrin receptor 2 (Y245X) mutant mouse model of hemochromatosis type 3. Drake, S.F., Morgan, E.H., Herbison, C.E., Delima, R., Graham, R.M., Chua, A.C., Leedman, P.J., Fleming, R.E., Bacon, B.R., Olynyk, J.K., Trinder, D. Am. J. Physiol. Gastrointest. Liver Physiol. (2007) [Pubmed]
  6. Hepatic expression of hemochromatosis genes in two mouse strains after phlebotomy and iron overload. Bondi, A., Valentino, P., Daraio, F., Porporato, P., Gramaglia, E., Carturan, S., Gottardi, E., Camaschella, C., Roetto, A. Haematologica (2005) [Pubmed]
  7. A compartmental model of iron regulation in the mouse. Lao, B.J., Kamei, D.T. J. Theor. Biol. (2006) [Pubmed]
  8. Liver expression of hepcidin and other iron genes in two mouse models of beta-thalassemia. De Franceschi, L., Daraio, F., Filippini, A., Carturan, S., Muchitsch, E.M., Roetto, A., Camaschella, C. Haematologica (2006) [Pubmed]
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