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Gene Review

ZNF7  -  zinc finger protein 7

Homo sapiens

Synonyms: HF.16, KOX4, Zinc finger protein 7, Zinc finger protein HF.16, Zinc finger protein KOX4, ...
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Disease relevance of ZNF7


High impact information on ZNF7


Biological context of ZNF7

  • On the basis of sequence similarity in the repeated zinc finger domain, we have identified and characterized two human cDNA clones (ZNF7 and ZNF8), both encoding proteins containing potential finger-like nucleic acid binding motifs [4].

Other interactions of ZNF7

  • The genes KOX 4 and KOX 9, mapped on chromosome 8q24, were found to be located within a DNA fragment of 450 kb [5].

Analytical, diagnostic and therapeutic context of ZNF7

  • Their potential biological significance is indicated by low apparent dissociation constants of S7-L7 (15 x 10(-9) M) and, respectively, ZNF7-L7 (2 x 10(-9) M) complexes and co-immunoprecipitation of proteins S7, ZNF7, and L7 from a cell lysate with an anti-L7 antibody [1].


  1. Specific interactions of the autoantigen L7 with multi-zinc finger protein ZNF7 and ribosomal protein S7. Witte, S., Krawinkel, U. J. Biol. Chem. (1997) [Pubmed]
  2. The human zinc-finger protein-7 gene is located 90 kb 3' of MYC and is not expressed in Burkitt lymphoma cell lines. Feduchi, E., Gallego, M.I., Lazo, P.A. Int. J. Cancer (1994) [Pubmed]
  3. Isolation of 115 human chromosome 8-specific expressed-sequence tags by exon amplification. Koyama, K., Sudo, K., Nakamura, Y. Genomics (1995) [Pubmed]
  4. cDNA isolation, expression analysis, and chromosomal localization of two human zinc finger genes. Lania, L., Donti, E., Pannuti, A., Pascucci, A., Pengue, G., Feliciello, I., La Mantia, G., Lanfrancone, L., Pelicci, P.G. Genomics (1990) [Pubmed]
  5. Chromosomal localization of two KOX zinc finger genes on chromosome bands 7q21-q22. Rousseau-Merck, M.F., Duro, D., Berger, R., Thiesen, H.J. Ann. Genet. (1995) [Pubmed]
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