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Gene Review:

Car12 - carbonic anyhydrase 12

Mus musculus

Synonyms: 2310047E01Rik, AI314958, CA XII, CA-XII, Ca12, ...

Halmi, P. et al., Parkkila, S. et al., Kallio, H. et al., Scheibe, R.J. et al.

Kallio, Pastorekova, Pastorek, Waheed, Sly, Mannisto, Heikinheimo, Parkkila,

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High impact information on Car12

Immunocytochemical and Western blotting results identified the presence of CA isoenzyme II in the cytoplasm of all four cell lines and CA XII on the plasma membrane in three of four cell lines [1].
Cytosolic CA II is known to participate in CSF secretion, and the high expression of CA XII in the choroid plexus suggests an analogous role for this membrane-bound isozyme [2].
CA XII was expressed in dentate granule cells, cortex and choroid plexus [2].
Kainic acid stimulated CA XII expression throughout the cortical layer I [2].
CA IV is present in both SR regions, whereas CA XII is not found in the SR [3].

Anatomical context of Car12

The CA XII-positive tissues included the brain, where the most prominent staining was seen in the choroid plexus, and the stomach, pancreas, liver and kidney [4].

Analytical, diagnostic and therapeutic context of Car12

Using RT-PCR we found CA XII mRNA in rat and mouse brain [2].

References

Carbonic anhydrase inhibitor suppresses invasion of renal cancer cells in vitro. Parkkila, S., Rajaniemi, H., Parkkila, A.K., Kivela, J., Waheed, A., Pastorekova, S., Pastorek, J., Sly, W.S. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
Expression of carbonic anhydrases II, IV, VII, VIII and XII in rat brain after kainic acid induced status epilepticus. Halmi, P., Parkkila, S., Honkaniemi, J. Neurochem. Int. (2006) [Pubmed]
Expression of Membrane-bound Carbonic Anhydrases IV, IX, and XIV in the Mouse Heart. Scheibe, R.J., Gros, G., Parkkila, S., Waheed, A., Grubb, J.H., Shah, G.N., Sly, W.S., Wetzel, P. J. Histochem. Cytochem. (2006) [Pubmed]
Expression of carbonic anhydrases IX and XII during mouse embryonic development. Kallio, H., Pastorekova, S., Pastorek, J., Waheed, A., Sly, W.S., Mannisto, S., Heikinheimo, M., Parkkila, S. BMC Dev. Biol. (2006) [Pubmed]

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