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Gene Review

ZNF131  -  zinc finger protein 131

Homo sapiens

Synonyms: ZBTB35, Zinc finger protein 131, pHZ-10
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High impact information on ZNF131

  • Therefore, it is possible that Znf131/ZNF131 plays a role during development and organogenesis as well as in the function of the adult central nervous system [1].
  • In human adult tissues a predominant expression of ZNF131 was seen in different brain areas, i.e., the occipital and temporal lobe, the nucleus caudatus, hippocampus, and the cerebellum as well as in testis and thymus [1].
  • Like many members of this protein family, Znf131 displays robust nuclear localization in cultured cells, but the mechanism(s) of Znf131 nuclear trafficking is unknown [2].
  • Finally, wild type Znf131, and not a Znf131 NLS-defective mutant (NLS-1m/NLS-2m) interacted preferentially with the nuclear import receptor Importin-alpha3 in vitro [2].
  • However, a Znf131 truncation mutant containing BR-2 and BR-3 efficiently targeted heterologous beta-gal-GFP fusion proteins to HeLa cell nuclei [2].

Biological context of ZNF131

  • Visual inspection of the Znf131 amino acid sequence revealed three basic regions (BR-1, -2 and -3) with the potential to serve as nuclear localization signals (NLS) [2].


  1. The murine BTB/POZ zinc finger gene Znf131: predominant expression in the developing central nervous system, in adult brain, testis, and thymus. Trappe, R., Buddenberg, P., Uedelhoven, J., Gläser, B., Buck, A., Engel, W., Burfeind, P. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  2. Nuclear trafficking of the POZ-ZF protein Znf131. Donaldson, N.S., Daniel, Y., Kelly, K.F., Graham, M., Daniel, J.M. Biochim. Biophys. Acta (2007) [Pubmed]
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