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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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CACNB1  -  calcium channel, voltage-dependent, beta 1...

Homo sapiens

Synonyms: CAB1, CACNLB1, CCHLB1, Calcium channel voltage-dependent subunit beta 1, Voltage-dependent L-type calcium channel subunit beta-1
 
 
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Disease relevance of CACNB1

  • Strains SIB1, SIC1, and SIS1 were identified as members of the genus Shewanella, and strain CAB1 was a member of the genus Arthrobacter [1].
 

High impact information on CACNB1

  • In order to investigate the potential roles played by other skeletal muscle calcium channels in MHS, we isolated cosmids containing the gene encoding the beta 1-subunit of skeletal muscle L-type voltage-dependent calcium channel (CACNLB1) [2].
  • Assignment of the human gene for the beta subunit of the voltage-dependent calcium channel (CACNLB1) to chromosome 17 using somatic cell hybrids and linkage mapping [3].
  • The putative transcription start site could be localized to 60 bp upstream of SA-CAB1 initiator codon by S1 mapping [4].
  • We previously reported that CAB1 and c-ERBB-2 genes were found to be located in a core amplified region of the 17q12 locus, which is frequently amplified in various cancers [5].
  • Alternative splicing of CACNB1 RNA occurs within the central domain at exon 7, and the 3' domain at exon 13, producing the variably expressed beta1a, beta1b and beta1c isoforms [6].
 

Biological context of CACNB1

  • CACNB1 is distributed over 25 kb and contains 13 exons [6].
  • Strains SIB1, SIS1, and CAB1 had a maximum growth rate at 20 degrees C and grew to the highest cell densities at the cultivation temperature of 0-4 degrees C. Strain SIS1 was capable of growing even at -5 degrees C. The growth profile of strain SIC1 was rather similar to that of a mesophilic bacterium [1].
  • METHODS: The polymorphic marker regions (TP53, CACNLB1, D18S58, DXS538, and DXS454) were amplified by polymerase chain reaction followed by separation using gel electrophoresis before LOH was identified [7].
 

Anatomical context of CACNB1

References

  1. Isolation and characterization of psychotrophic bacteria from oil-reservoir water and oil sands. Kato, T., Haruki, M., Imanaka, T., Morikawa, M., Kanaya, S. Appl. Microbiol. Biotechnol. (2001) [Pubmed]
  2. Genetic mapping of the beta 1- and gamma-subunits of the human skeletal muscle L-type voltage-dependent calcium channel on chromosome 17q and exclusion as candidate genes for malignant hyperthermia susceptibility. Iles, D.E., Segers, B., Sengers, R.C., Monsieurs, K., Heytens, L., Halsall, P.J., Hopkins, P.M., Ellis, F.R., Hall-Curran, J.L., Stewart, A.D. Hum. Mol. Genet. (1993) [Pubmed]
  3. Assignment of the human gene for the beta subunit of the voltage-dependent calcium channel (CACNLB1) to chromosome 17 using somatic cell hybrids and linkage mapping. Gregg, R.G., Powers, P.A., Hogan, K. Genomics (1993) [Pubmed]
  4. Isolation and characterization of a gene encoding a chlorophyll a/b-binding protein from mustard and the targeting of the encoded protein to the thylakoid membrane of pea chloroplasts in vitro. Gauly, A., Batschauer, A., von Arnim, A., Kössel, H. Plant Mol. Biol. (1992) [Pubmed]
  5. Identification of the CAB2/hCOS16 gene required for the repair of DNA double-strand breaks on a core amplified region of the 17q12 locus in breast and gastric cancers. Nezu, M., Nishigaki, M., Ishizuka, T., Kuwahara, Y., Tanabe, C., Aoyagi, K., Sakamoto, H., Saito, Y., Yoshida, T., Sasaki, H., Terada, M. Jpn. J. Cancer Res. (2002) [Pubmed]
  6. Structure and alternative splicing of the gene encoding the human beta1 subunit of voltage dependent calcium channels. Hogan, K., Greg, R.G., Powers, P.A. Neurosci. Lett. (1999) [Pubmed]
  7. Loss of heterozygosity on the X chromosome is an independent prognostic factor in ovarian carcinoma: from the Danish "MALOVA" Ovarian Carcinoma Study. Høgdall, E.V., Ryan, A., Kjaer, S.K., Blaakaer, J., Christensen, L., Bock, J.E., Glud, E., Jacobs, I.J., Høgdall, C.K. Cancer (2004) [Pubmed]
  8. A new self-threading acetabulum (CAB 1) in total hip replacement. Agrifoglio, E. Italian journal of orthopaedics and traumatology. (1990) [Pubmed]
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