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Chemical Compound Review

4-HYDROXYAMINOQUINOLINE-1-OXIDE     (NE)-N-(1-hydroxyquinolin-4...

Synonyms: AC1NSEBJ, CCRIS 1068, CHEBI:28469, LS-1278, NSC-177384, ...
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Analytical, diagnostic and therapeutic context of 4-HYDROXYAMINOQUINOLINE-1-OXIDE


  1. Malignant fibrous histiocytomas induced by 4-(hydroxyamino)quinoline 1-oxide in rats. Konishi, Y., Maruyama, H., Mii, Y., Miyauchi, Y., Yokose, Y., Masuhara, K. J. Natl. Cancer Inst. (1982) [Pubmed]
  2. Interaction of RecA protein with pBR322 DNA modified by N-hydroxy-2-acetylaminofluorene and 4-hydroxyaminoquinoline 1-oxide. Kojima, M., Suzuki, M., Morita, T., Ogawa, T., Ogawa, H., Tada, M. Nucleic Acids Res. (1990) [Pubmed]
  3. Temporal dissociation between cell proliferation and eosinophilic foci development in the exocrine pancreas of rats initiated with 4-hydroxyaminoquinoline 1-oxide and administered soybean trypsin inhibitor. Furukawa, F., Nishikawa, A., Imaida, K., Imazawa, T., Shinoda, K., Takahashi, M., Hayashi, Y. Carcinogenesis (1993) [Pubmed]
  4. Expression of the transin, c-fos, and c-jun genes in rat transplantable osteosarcomas and malignant fibrous histiocytomas. Honoki, K., Tsutsumi, M., Tsujiuchi, T., Kondoh, S., Shiraiwa, K., Miyauchi, Y., Mii, Y., Tamai, S., Konishi, Y., Bowden, G.T. Mol. Carcinog. (1992) [Pubmed]
  5. Reduction of 4-nitroquinoline 1-oxide to 4-hydroxyaminoquinoline 1-oxide in lysates of cytomegalovirus-infected cells. Speelman, D.J., Lund, H., Culling, A., Kittredge, J.S., Williams, B.J., Albrecht, T. J. Gen. Virol. (1983) [Pubmed]
  6. Spontaneous neurinoma in an African lungfish, Protopterus annectens, and DNA repair studies on normal and neoplastic tissues. Ishikawa, T., Masahito, P., Nemoto, N., Matsumoto, J., Shima, A. J. Natl. Cancer Inst. (1986) [Pubmed]
  7. Relationship between sensitivity of cells from patients with hereditary cutaneous malignant melanoma to killing and mutations by 4-nitroquinoline 1-oxide and adduct formation. Sato, K., Howell, J.N., Greene, M.H., Maher, V.M., McCormick, J.J. Cancer Res. (1988) [Pubmed]
  8. Evidence of repair of DNA damage induced by 4-hydroxyaminoquinoline 1-oxide in guinea pig pancreatic slices in vitro. Iqbal, Z.M., Majdan, M., Epstein, S.S. Cancer Res. (1976) [Pubmed]
  9. Production of pancreatic acinar cell carcinoma by combined administration of 4-hydroxyaminoquinoline 1-oxide and azaserine in partial pancreatectomized rats. Konish, Y., Denda, A., Inui, S., Takahashi, S., Ueda, N., Namiki, M. Cancer Lett. (1978) [Pubmed]
  10. Ultrastructures of atypical acinar cell nodules in rat pancreas induced by 4-hydroxyaminoquinoline-1-oxide. Shinozuka, H., Popp, J.A., Konishi, Y. Lab. Invest. (1976) [Pubmed]
  11. Cytomegalovirus-enhanced induction of chromosome aberrations in human peripheral blood lymphocytes treated with potent genotoxic agents. Deng, C.Z., AbuBakar, S., Fons, M.P., Boldogh, I., Hokanson, J., Au, W.W., Albrecht, T. Environ. Mol. Mutagen. (1992) [Pubmed]
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  13. Species and organ differences in DNA adduct formation and repair after treatment with 4-hydroxyaminoquinoline 1-oxide. Qin, X.S., Nakatsuru, Y., Tada, M., Ishikawa, T. Jpn. J. Cancer Res. (1990) [Pubmed]
  14. Sequential alteration of apoptosis, p53 expression, and cell proliferation in the rat pancreas treated with 4-hydroxyaminoquinoline 1-oxide. Imazawa, T., Nishikawa, A., Toyoda, K., Furukawa, F., Mitsui, M., Hirose, M. Toxicologic pathology. (2003) [Pubmed]
  15. Immunohistochemical detection of carcinogen-DNA adducts and DNA repair in mouse skin. Nakagawa, K., Nakatsuru, Y., Ishikawa, T. J. Invest. Dermatol. (1989) [Pubmed]
  16. REgeneration of the guinea pig parotid gland after 4-hydroxyaminoquinoline-1-oxide-induced necrosis. Rao, M.S., Reddy, J.K. Proc. Soc. Exp. Biol. Med. (1976) [Pubmed]
  17. Formation of 8-hydroxyguanine residues in cellular DNA exposed to the carcinogen 4-nitroquinoline 1-oxide. Kohda, K., Tada, M., Kasai, H., Nishimura, S., Kawazoe, Y. Biochem. Biophys. Res. Commun. (1986) [Pubmed]
  18. Metabolism of 4-hydroxyaminoquinoline-1-oxide and its binding to DNA in chick embryos. Kitani, H., Tada, M., Morita, T., Koshida, Y. Chem. Biol. Interact. (1983) [Pubmed]
  19. Site-specific DNA damage and 8-hydroxydeoxyguanosine formation by hydroxylamine and 4-hydroxyaminoquinoline 1-oxide in the presence of Cu(II): role of active oxygen species. Yamamoto, K., Inoue, S., Kawanishi, S. Carcinogenesis (1993) [Pubmed]
  20. Conversion of 4-nitroquinoline 1-oxide (4NQO) to 4-hydroxyaminoquinoline 1-oxide by a dicumarol-resistant hepatic 4NQO nitroreductase in rats and mice. Benson, A.M. Biochem. Pharmacol. (1993) [Pubmed]
  21. Selective 8-hydroxyguanine formation in pancreatic DNA due to a single intravenous administration of 4-hydroxyaminoquinoline 1-oxide in rats. Nakae, D., Andoh, N., Mizumoto, Y., Endoh, T., Shimoji, N., Horiguchi, K., Shiraiwa, K., Tamura, K., Denda, A., Konishi, Y. Cancer Lett. (1994) [Pubmed]
  22. Effect of aluminium chloride on binding of 4-hydroxyamino-quinoline 1-oxide to nucleotides. Yamane, Y., Ohtawa, M. Gann = Gan. (1979) [Pubmed]
  23. 5-Chloro-7-iodo-8-hydroxyquinoline (clioquinol) inhibits the nerve growth factor-induced stimulation of RNA synthesis in neonatal rat superior cervical ganglion, in vitro--comparison with effects of methylmercuric chloride and 4-hydroxyaminoquinoline-N-oxide. Hori, S., Kayanuma, K., Ohtani, S., Sugiura, H., Tsubaki, T. The Journal of toxicological sciences. (1987) [Pubmed]
  24. Overexpression of matrix metalloproteinase (MMP)-9 correlates with metastatic potency of spontaneous and 4-hydroxyaminoquinoline 1-oxide (4-HAQO)-induced transplantable osteosarcomas in rats. Kido, A., Tsutsumi, M., Iki, K., Takahama, M., Tsujiuchi, T., Morishita, T., Tamai, S., Konishi, Y. Cancer Lett. (1999) [Pubmed]
  25. Atypical acinar cell lesions of the pancreas in mice induced by 4-hydroxyaminoquinoline-1-oxide. Rao, M.S., Subbarao, V., Scarpelli, D.G. Int. J. Pancreatol. (1987) [Pubmed]
  26. Nucleolar segregation as an early marker for DNA damage; an experimental study in rats treated with 4-hydroxyaminoquinoline 1-oxide. Imazawa, T., Nishikawa, A., Tada, M., Takahashi, M., Hayashi, Y. Virchows Arch. (1995) [Pubmed]
  27. In vivo studies on age dependency of DNA repair with age in mouse skin. Ishikawa, T., Sakurai, J. Cancer Res. (1986) [Pubmed]
  28. Pancreatic carcinoma induced by 4-hydroxyaminoquinoline 1-oxide after partial pancreatectomy and splenectomy in rats. Konishi, Y., Denda, A., Inui, S., Takahashi, S., Kondo, H. Gann = Gan. (1976) [Pubmed]
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