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Gene Review:

THUMPD2 - THUMP domain containing 2

Homo sapiens

Synonyms: C2orf8, MGC2454, THUMP domain-containing protein 2

Zhang, Y. et al.

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High impact information on THUMPD2

We localized this gene (C2orf8 encoding 288L6 SAM-methyltransferase) to chromosome 2p22-->p21 by FISH, and sublocalized it to BAC RP11 288L6 flanked by D2S2238 and D2S2331 [1].
Computational analysis of aligned ESTs identified ten exons in the hypothetical C2orf8 gene [1].
Sequence analyses of C2orf8 excluded coding region mutations as causative of GINGF [1].
C2orf8 is expressed in a variety of tissues including brain, colon, gingiva, heart, kidney, liver, lung, placenta, small intestine, spleen, and thymus [1].

Analytical, diagnostic and therapeutic context of THUMPD2

Alternative transcription and tissue specific expression of C2orf8 were detected by RT-PCR and Northern blot analyses [1].

References

Localization, genomic organization, and alternative transcription of a novel human SAM-dependent methyltransferase gene on chromosome 2p22-->p21. Zhang, Y., Gorry, M.C., Hart, P.S., Pettenati, M.J., Wang, L., Marks, J.J., Lu, X., Hart, T.C. Cytogenet. Cell Genet. (2001) [Pubmed]

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