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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Calm4  -  calmodulin 4

Mus musculus

Synonyms: 2310037J09Rik, AI649108, Calcium-binding protein Dd112, Calmodulin-4, DD112, ...
 
 
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High impact information on Calm4

  • By Southern blot and computational genome sequence analysis, a highly related gene, Scarf2, was found 15 kb downstream of Scarf on mouse chromosome 13 [1].
  • By performing a suppression subtractive hybridization screen we identified a novel mouse gene, Scarf (skin calmodulin-related factor), which has homology to calmodulin (CaM)-like Ca2+-binding protein genes and is exclusively expressed in differentiating keratinocytes in the epidermis [1].
  • The functionality of Scarf EF-hand domains was assayed with a radioactive Ca2+-binding method [1].
  • These results showed substantial overlap with the previously reported Scarf gene expression [Hwang, M., Morasso, M.I., 2003. The novel murine Ca2+-binding protein, Scarf, is differentially expressed during epidermal differentiation. J. Biol. Chem. 278, 47827-47833] [2].
 

Associations of Calm4 with chemical compounds

 

Anatomical context of Calm4

  • Interestingly, Scarf and Scarf2 were also detected in the tongue and oral epithelia, rib bone undergoing ossification and in the medullar region of thymus [2].

References

  1. The novel murine Ca2+-binding protein, Scarf, is differentially expressed during epidermal differentiation. Hwang, M., Morasso, M.I. J. Biol. Chem. (2003) [Pubmed]
  2. The temporal and spatial expression of the novel Ca++-binding proteins, Scarf and Scarf2, during development and epidermal differentiation. Hwang, M., Kalinin, A., Morasso, M.I. Gene Expr. Patterns (2005) [Pubmed]
  3. Role of Scarf and its binding target proteins in epidermal calcium homeostasis. Hwang, J., Kalinin, A., Hwang, M., Anderson, D.E., Kim, M.J., Stojadinovic, O., Tomic-Canic, M., Lee, S.H., Morasso, M.I. J. Biol. Chem. (2007) [Pubmed]
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