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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Fabp7  -  fatty acid binding protein 7, brain

Rattus norvegicus

Synonyms: B-FABP, BLBP, Blbp, Brain lipid-binding protein, Brain-type fatty acid-binding protein, ...
 
 
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High impact information on Fabp7

  • A population of self-renewing radial cells, distinct from an earlier pseudo-stratified neuroepithelium, that resemble radial glial cells in morphology but do not express GLAST, BLBP, or 3CB2, is revealed [1].
  • GLAST/BLBP-positive radial glia first appear in the ventral cord at E14, and these cells gradually transform through one or more intermediate stages into differentiated astrocytes [1].
  • Clone RG3.6 exhibits polarized morphology and expresses the radial glial markers nestin and brain lipid binding protein [2].
  • Most of these cells express vimentin and brain lipid binding protein [3].
  • B-FABP mRNA was transiently expressed in perinatal gray as well as white matter and the expression in glial cells persists only in the olfactory nerve fiber layer at the adult stage [4].
 

Biological context of Fabp7

References

  1. Differentiation of radial glia from radial precursor cells and transformation into astrocytes in the developing rat spinal cord. Barry, D., McDermott, K. Glia (2005) [Pubmed]
  2. Embryonic radial glia bridge spinal cord lesions and promote functional recovery following spinal cord injury. Hasegawa, K., Chang, Y.W., Li, H., Berlin, Y., Ikeda, O., Kane-Goldsmith, N., Grumet, M. Exp. Neurol. (2005) [Pubmed]
  3. Chronic hypoxia up-regulates fibroblast growth factor ligands in the perinatal brain and induces fibroblast growth factor-responsive radial glial cells in the sub-ependymal zone. Ganat, Y., Soni, S., Chacon, M., Schwartz, M.L., Vaccarino, F.M. Neuroscience (2002) [Pubmed]
  4. Spatio-temporally differential expression of genes for three members of fatty acid binding proteins in developing and mature rat brains. Owada, Y., Yoshimoto, T., Kondo, H. J. Chem. Neuroanat. (1996) [Pubmed]
  5. Sequential signaling through Notch1 and erbB receptors mediates radial glia differentiation. Patten, B.A., Peyrin, J.M., Weinmaster, G., Corfas, G. J. Neurosci. (2003) [Pubmed]
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