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Gene Review

Fabp7  -  fatty acid binding protein 7, brain

Mus musculus

Synonyms: B-FABP, BFABP, BLBP, Blbp, Brain lipid-binding protein, ...
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Disease relevance of Fabp7

  • BLBP was also detected in EGFR-positive cell lines derived from Nf1:p53 double mutant mice and human MPNST [1].
  • To further define the role of MRG on mammary gland differentiation, a MRG transgenic mice model under the control of mouse mammary tumor virus promoter was established and the effect of MRG on mammary gland differentiation was investigated at histological and molecular levels [2].
  • Overexpression of MRG in human breast cancer cells induced differentiation with changes in cellular morphology and a significant increase in the production of lipid droplets [3].

High impact information on Fabp7


Chemical compound and disease context of Fabp7


Biological context of Fabp7


Anatomical context of Fabp7


Associations of Fabp7 with chemical compounds

  • The partially overlapping expression pattern with that of cellular retinoid binding proteins suggests that B-FABP is involved in the metabolism of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development [11].
  • Between 3 h and 1 week after a single injection of permanent S-phase marker bromodeoxyuridine (BrdU), the number of BrdU-labeled BLBP-positive cells did not change, consistent with the idea that both markers here are associated with the maintained precursor cell pool [12].
  • The identity of radial glial cells was proven by their immunoreactivity for antibodies against astrocyte-specific glutamate transporter, brain lipid-binding protein, and nestin [13].
  • MRG-transfected cells or MRG protein treated cells were much more sensitive to docosahexaenoic acid-induced growth inhibition than MRG-negative or untreated control cells [3].
  • Brain B-FABP bound NBD-stearic and cis-parinaric acid with K D values near 0.01 and 0.7 microM, respectively [14].

Regulatory relationships of Fabp7


Other interactions of Fabp7

  • In contrast to vimentin, at later stages BLBP and GLAST were found in RG-like cell somata but not in their processes [17].
  • B-FABP mRNA and protein were found in glial cells of the peripheral nervous system such as satellite cells of spinal and cranial ganglia and ensheathing cells of the olfactory nerve layer from as early as embryonic day 11 until adulthood [11].
  • Although a novel brain-specific fatty acid-binding protein (B-FABP) was recently cloned, the identity of a second fatty acid-binding protein detected with antibodies to the heart (H-FABP) has not been clearly resolved [18].
  • In infected brains, we found upregulated expression of genes encoding brain fatty acid binding protein (B-FABP), beta2-microglobulin (beta2m) and, as described previously, the chemokine IP-10 [19].
  • Moreover, the colocalization of DPI and brain-type FABP (B-FABP) was observed in most of the non-neuronal supporting cells mentioned above, indicating that DBI and B-FABP are cooperatively involved in the energy metabolism of astrocytes and related cells, which are thought to support neuronal development and functions [20].

Analytical, diagnostic and therapeutic context of Fabp7


  1. Brain lipid binding protein in axon-Schwann cell interactions and peripheral nerve tumorigenesis. Miller, S.J., Li, H., Rizvi, T.A., Huang, Y., Johansson, G., Bowersock, J., Sidani, A., Vitullo, J., Vogel, K., Parysek, L.M., DeClue, J.E., Ratner, N. Mol. Cell. Biol. (2003) [Pubmed]
  2. Induction of mammary gland differentiation in transgenic mice by the fatty acid-binding protein MRG. Wang, M., Liu, Y.E., Goldberg, I.D., Shi, Y.E. J. Biol. Chem. (2003) [Pubmed]
  3. Induction of mammary differentiation by mammary-derived growth inhibitor-related gene that interacts with an omega-3 fatty acid on growth inhibition of breast cancer cells. Wang, M., Liu, Y.E., Ni, J., Aygun, B., Goldberg, I.D., Shi, Y.E. Cancer Res. (2000) [Pubmed]
  4. Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells. Anthony, T.E., Mason, H.A., Gridley, T., Fishell, G., Heintz, N. Genes Dev. (2005) [Pubmed]
  5. Brain lipid-binding protein (BLBP): a novel signaling system in the developing mammalian CNS. Feng, L., Hatten, M.E., Heintz, N. Neuron (1994) [Pubmed]
  6. PAM14, a novel MRG- and Rb-associated protein, is not required for development and T-cell function in mice. Tominaga, K., Magee, D.M., Matzuk, M.M., Pereira-Smith, O.M. Mol. Cell. Biol. (2004) [Pubmed]
  7. Role of Fabp7, a downstream gene of Pax6, in the maintenance of neuroepithelial cells during early embryonic development of the rat cortex. Arai, Y., Funatsu, N., Numayama-Tsuruta, K., Nomura, T., Nakamura, S., Osumi, N. J. Neurosci. (2005) [Pubmed]
  8. POU transcription factors control expression of CNS stem cell-specific genes. Josephson, R., Müller, T., Pickel, J., Okabe, S., Reynolds, K., Turner, P.A., Zimmer, A., McKay, R.D. Development (1998) [Pubmed]
  9. Reelin signaling directly affects radial glia morphology and biochemical maturation. Hartfuss, E., Förster, E., Bock, H.H., Hack, M.A., Leprince, P., Luque, J.M., Herz, J., Frotscher, M., Götz, M. Development (2003) [Pubmed]
  10. Characterization of CNS precursor subtypes and radial glia. Hartfuss, E., Galli, R., Heins, N., Götz, M. Dev. Biol. (2001) [Pubmed]
  11. The expression pattern of a novel gene encoding brain-fatty acid binding protein correlates with neuronal and glial cell development. Kurtz, A., Zimmer, A., Schnütgen, F., Brüning, G., Spener, F., Müller, T. Development (1994) [Pubmed]
  12. Type-2 cells as link between glial and neuronal lineage in adult hippocampal neurogenesis. Steiner, B., Klempin, F., Wang, L., Kott, M., Kettenmann, H., Kempermann, G. Glia (2006) [Pubmed]
  13. Expression patterns of erythropoietin and its receptor in the developing midbrain. Knabe, W., Knerlich, F., Washausen, S., Kietzmann, T., Sirén, A.L., Brunnett, G., Kuhn, H.J., Ehrenreich, H. Anat. Embryol. (2004) [Pubmed]
  14. Isolation and characterization of two fatty acid binding proteins from mouse brain. Myers-Payne, S.C., Hubbell, T., Pu, L., Schnütgen, F., Börchers, T., Wood, W.G., Spener, F., Schroeder, F. J. Neurochem. (1996) [Pubmed]
  15. Fibroblast growth factor 2 is required for maintaining the neural stem cell pool in the mouse brain subventricular zone. Zheng, W., Nowakowski, R.S., Vaccarino, F.M. Dev. Neurosci. (2004) [Pubmed]
  16. Heterologous expression and characterisation of mouse brain fatty acid binding protein. Schnütgen, F., Börchers, T., Müller, T., Spener, F. Biol. Chem. Hoppe-Seyler (1996) [Pubmed]
  17. Radial glia-like cells at the base of the lateral ventricles in adult mice. Sundholm-Peters, N.L., Yang, H.K., Goings, G.E., Walker, A.S., Szele, F.G. J. Neurocytol. (2004) [Pubmed]
  18. Isolation and identification of a mouse brain protein recognized by antisera to heart fatty acid-binding protein. Pu, L., Annan, R.S., Carr, S.A., Frolov, A., Wood, W.G., Spener, F., Schroeder, F. Lipids (1999) [Pubmed]
  19. Identification of differentially expressed genes in brains of newborn Borna disease virus-infected rats in the absence of inflammation. Jehle, C., Herpfer, I., Rauer, M., Schwemmle, M., Sauder, C. Arch. Virol. (2003) [Pubmed]
  20. Cellular localization of the diazepam binding inhibitor in glial cells with special reference to its coexistence with brain-type fatty acid binding protein. Yanase, H., Shimizu, H., Yamada, K., Iwanaga, T. Arch. Histol. Cytol. (2002) [Pubmed]
  21. Differentiating neurons activate transcription of the brain lipid-binding protein gene in radial glia through a novel regulatory element. Feng, L., Heintz, N. Development (1995) [Pubmed]
  22. Cloning and characterization of a cDNA encoding a novel fatty acid binding protein from rat brain. Bennett, E., Stenvers, K.L., Lund, P.K., Popko, B. J. Neurochem. (1994) [Pubmed]
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