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Gene Review

Nes  -  nestin

Rattus norvegicus

Synonyms: Nestin
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Disease relevance of Nes


High impact information on Nes


Chemical compound and disease context of Nes

  • Nestin/bromodeoxyuridine (BrdU)-negative A1 astrocytes were found further than approximately 100 microm from the stab wound and showed an upregulation of K(IR) currents within the first day post-injury (PI), correlating with an increased resting [K+]e. Their number declined from 62% of total astrocytes in control rats to 41% in rats at 7 days PI [9].
  • Expression of nestin in the hippocampal formation of rats submitted to the pilocarpine model of epilepsy [10].
  • In summary, there is an induction of neuropoietic activity in a rat intracranial glioma model that results in an infiltration and accumulation of abnormal nestin and GFAP expressing cells with proliferative potential along the dorsal and medial border of intracranial C6 glioma [11].
  • It was found that experimental epilepsy or pinealectomy procedure enhanced nestin immunoreactivity, but exogenous melatonin treatment (30 microg/100 g body weight, i.p.) following pinealectomy inhibited increased nestin expression induced by melatonin deprival in vermis region of newborn rat cerebellum (P < 0.001) [12].

Biological context of Nes


Anatomical context of Nes


Associations of Nes with chemical compounds


Physical interactions of Nes

  • Both nestin and the neural RNA-binding protein Musashi1 (Msi1) are expressed in neural stem cells in the subventricular zone [20].

Co-localisations of Nes


Regulatory relationships of Nes


Other interactions of Nes


Analytical, diagnostic and therapeutic context of Nes


  1. Embryonic intermediate filaments, nestin and vimentin, expression in the spinal cords of rats with experimental autoimmune encephalomyelitis. Shin, T.K., Lee, Y.D., Sim, K.B. J. Vet. Sci. (2003) [Pubmed]
  2. Ependyma as a possible morphological basis of ischemic preconditioning tolerance in rat spinal cord ischemia model: nestin and Fluoro-Jade B observations. Orendácová, J., Raceková, E., Kuchárova, K., Pousová, B., Ondrejcák, T., Martoncíková, M., Daxnerová, Z., Marsala, J. Cell. Mol. Neurobiol. (2004) [Pubmed]
  3. Nestin immunoreactivity in local neurons of the adult rat striatum after remote cortical injury. Kuroda, T., Nakamura, H., Itoh, K., Le, W.R., Yoshimura, S., Takenaka, K., Sakai, N. J. Chem. Neuroanat. (2002) [Pubmed]
  4. Resident nestin+ neural-like cells and fibers are detected in normal and damaged rat myocardium. El-Helou, V., Dupuis, J., Proulx, C., Drapeau, J., Clement, R., Gosselin, H., Villeneuve, L., Manganas, L., Calderone, A. Hypertension (2005) [Pubmed]
  5. Region-specific differentiation of the hippocampal stem cell line HiB5 upon implantation into the developing mammalian brain. Renfranz, P.J., Cunningham, M.G., McKay, R.D. Cell (1991) [Pubmed]
  6. The distribution of novel intermediate filament proteins defines subpopulations of myenteric neurons in rat intestine. Eaker, E.Y., Sallustio, J.E. Gastroenterology (1994) [Pubmed]
  7. Thyroid hormone activates oligodendrocyte precursors and increases a myelin-forming protein and NGF content in the spinal cord during experimental allergic encephalomyelitis. Calza, L., Fernandez, M., Giuliani, A., Aloe, L., Giardino, L. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  8. Homeotic factor ATBF1 induces the cell cycle arrest associated with neuronal differentiation. Jung, C.G., Kim, H.J., Kawaguchi, M., Khanna, K.K., Hida, H., Asai, K., Nishino, H., Miura, Y. Development (2005) [Pubmed]
  9. Voltage-dependent potassium currents in hypertrophied rat astrocytes after a cortical stab wound. Anderová, M., Antonova, T., Petrík, D., Neprasová, H., Chvátal, A., Syková, E. Glia (2004) [Pubmed]
  10. Expression of nestin in the hippocampal formation of rats submitted to the pilocarpine model of epilepsy. Scorza, C.A., Arida, R.M., Cavalheiro, E.A., Naffah-Mazzacoratti, M.G., Scorza, F.A. Neurosci. Res. (2005) [Pubmed]
  11. Up-regulation of neuropoiesis generating glial progenitors that infiltrate rat intracranial glioma. Duntsch, C., Zhou, Q., Weimar, J.D., Frankel, B., Robertson, J.H., Pourmotabbed, T. J. Neurooncol. (2005) [Pubmed]
  12. Beneficial effects of melatonin on morphological changes in postnatal cerebellar tissue owing to epileptiform activity during pregnancy in rats: light and immunohistochemical study. Uyanikgil, Y., Turgut, M., Ateş, U., Baka, M., Yurtseven, M.E. Brain Res. Dev. Brain Res. (2005) [Pubmed]
  13. Nestin expression in pancreatic stellate cells and angiogenic endothelial cells. Lardon, J., Rooman, I., Bouwens, L. Histochem. Cell Biol. (2002) [Pubmed]
  14. Regulation of nestin expression after cortical ablation in adult rat brain. Douen, A.G., Dong, L., Vanance, S., Munger, R., Hogan, M.J., Thompson, C.S., Hakim, A.M. Brain Res. (2004) [Pubmed]
  15. Class VI intermediate filament protein nestin is induced during activation of rat hepatic stellate cells. Niki, T., Pekny, M., Hellemans, K., Bleser, P.D., Berg, K.V., Vaeyens, F., Quartier, E., Schuit, F., Geerts, A. Hepatology (1999) [Pubmed]
  16. Nestin-immunoreactive cells in rat pituitary are neither hormonal nor typical folliculo-stellate cells. Krylyshkina, O., Chen, J., Mebis, L., Denef, C., Vankelecom, H. Endocrinology (2005) [Pubmed]
  17. Nestin expression in hippocampal astrocytes after injury depends on the age of the hippocampus. Abdel-Rahman, A., Rao, M.S., Shetty, A.K. Glia (2004) [Pubmed]
  18. Low-protein diet during early life causes a reduction in the frequency of cells immunopositive for nestin and CD34 in both pancreatic ducts and islets in the rat. Joanette, E.A., Reusens, B., Arany, E., Thyssen, S., Remacle, R.C., Hill, D.J. Endocrinology (2004) [Pubmed]
  19. Aberrant nestin expression during ethylnitrosourea-(ENU)-induced neurocarcinogenesis. Jang, T., Litofsky, N.S., Smith, T.W., Ross, A.H., Recht, L.D. Neurobiol. Dis. (2004) [Pubmed]
  20. Differential expression of Musashi1 and nestin in the adult rat hippocampus after ischemia. Yagita, Y., Kitagawa, K., Sasaki, T., Miyata, T., Okano, H., Hori, M., Matsumoto, M. J. Neurosci. Res. (2002) [Pubmed]
  21. Activation of embryonic intermediate filaments contributes to glial scar formation after spinal cord injury in rats. Kim, D.H., Heo, S.D., Ahn, M.J., Sim, K.B., Shin, T.K. J. Vet. Sci. (2003) [Pubmed]
  22. Nestin expression in rat adrenal gland. Bertelli, E., Regoli, M., Lucattelli, M., Bastianini, A., Fonzi, L. Histochem. Cell Biol. (2002) [Pubmed]
  23. Expression of an embryonic intermediate filament protein in amygdaloid kindled rats. Umeoka, S., Miyamoto, O., Nakagawa, T., Janjua, N.A., Nagao, S., Itano, T. Epilepsy Res. (2001) [Pubmed]
  24. Sonic hedgehog-induced neural precursor proliferation after adult rodent spinal cord injury. Bambakidis, N.C., Wang, R.Z., Franic, L., Miller, R.H. J. Neurosurg. (2003) [Pubmed]
  25. Activation, Proliferation and Commitment of Endogenous Stem/Progenitor Cells to the Oligodendrocyte Lineage by TS1 in a Rat Model of Dysmyelination. Espinosa-Jeffrey, A., Zhao, P., Awosika, W., Wu, N., Macias, F., Cepeda, C., Levine, M., de Vellis, J. Dev. Neurosci. (2006) [Pubmed]
  26. A high molecular weight intermediate filament-associated protein in BHK-21 cells is nestin, a type VI intermediate filament protein. Limited co-assembly in vitro to form heteropolymers with type III vimentin and type IV alpha-internexin. Steinert, P.M., Chou, Y.H., Prahlad, V., Parry, D.A., Marekov, L.N., Wu, K.C., Jang, S.I., Goldman, R.D. J. Biol. Chem. (1999) [Pubmed]
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