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Gene Review:

PIN4 - auxin efflux carrier component 4

Arabidopsis thaliana

Synonyms: ARABIDOPSIS PIN-FORMED 4, ATPIN4, AUXIN TRANSPORTER SPLICE VARIANT B, F10A8.27, PIN-FORMED 4

Bassuner, B.M. et al., Weijers, D. et al., Friml, J. et al., Hotta, T. et al.

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High impact information on PIN4

Here, we characterize a novel member of the PIN family of putative auxin efflux carriers, Arabidopsis PIN4, that is localized in developing and mature root meristems [1].
Chemical and genetic inhibition revealed that auxin transport activity, in particular that of the PIN-FORMED1 (PIN1) and PIN4 proteins, is a major factor in the maintenance of these gradients [2].
Furthermore, two molecular markers were assayed to monitor transcriptional auxin responses and formation of a root meristem in this process: the LENNY allele of PIN4, a transposon insertion creating a fusion to the reporter gene GUS; and DR5::GUS, a synthetic reporter of auxin-induced transcription [3].
In zygotic embryogenesis, PIN4 expression is confined to the center of the root meristem and begins to be detectable by the globular stage of embryogenesis, while DR5::GUS expression marks an "auxin perception maximum" in the more distal regions of the root [3].
CsPIN2, AtPIN3, AtPIN4 and AtPIN7 fall within the same clade [4].

References

AtPIN4 mediates sink-driven auxin gradients and root patterning in Arabidopsis. Friml, J., Benková, E., Blilou, I., Wisniewska, J., Hamann, T., Ljung, K., Woody, S., Sandberg, G., Scheres, B., Jürgens, G., Palme, K. Cell (2002) [Pubmed]
Maintenance of embryonic auxin distribution for apical-basal patterning by PIN-FORMED-dependent auxin transport in Arabidopsis. Weijers, D., Sauer, M., Meurette, O., Friml, J., Ljung, K., Sandberg, G., Hooykaas, P., Offringa, R. Plant Cell (2005) [Pubmed]
Auxin and root initiation in somatic embryos of Arabidopsis. Bassuner, B.M., Lam, R., Lukowitz, W., Yeung, E.C. Plant Cell Rep. (2007) [Pubmed]
Isolation of auxin efflux carrier cDNA from cucumber. Hotta, T., Kim, D.H., Kamada, M., Fujii, N., Kim, K.M., Takahashi, H. Biol. Sci. Space (2003) [Pubmed]

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