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Gene Review

PTDSS2  -  phosphatidylserine synthase 2

Homo sapiens

Synonyms: PSS-2, PSS2, Phosphatidylserine synthase 2, PtdSer synthase 2, Serine-exchange enzyme II
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High impact information on PTDSS2


Anatomical context of PTDSS2

  • It was found that the levels of PSS1 and PSS2 transcripts were higher in immature and mature oocytes, respectively [4].
  • In all cell lines, regardless of their content of PSS1 and/or PSS2, apoptosis occurred to approximately the same extent, and within approximately the same time frame, as in parental CHO-K1 cells [3].

Analytical, diagnostic and therapeutic context of PTDSS2

  • The distribution of PSS1- and PSS2-derived peptides has been investigated by immunohistochemistry using two antisera directed against SS1 and the sequence 54-66 of PSS2 (PSS2(54-66)), respectively [5].


  1. Occurrence of two somatostatin variants in the frog brain: characterization of the cDNAs, distribution of the mRNAs, and receptor-binding affinities of the peptides. Tostivint, H., Lihrmann, I., Bucharles, C., Vieau, D., Coulouarn, Y., Fournier, A., Conlon, J.M., Vaudry, H. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  2. Phospholipid biosynthesis in mammalian cells. Vance, J.E., Vance, D.E. Biochem. Cell Biol. (2004) [Pubmed]
  3. Externalization of phosphatidylserine during apoptosis does not specifically require either isoform of phosphatidylserine synthase. Grandmaison, P.A., Nanowski, T.S., Vance, J.E. Biochim. Biophys. Acta (2004) [Pubmed]
  4. Ca2+-dependent phosphatidylserine synthesis in immature and mature starfish oocytes. Dygas, A., Barańska, J., Santella, L. Acta Biochim. Pol. (2003) [Pubmed]
  5. Expression and processing of the [Pro(2),Met(13)]somatostatin-14 precursor in the intermediate lobe of the frog pituitary. Tostivint, H., Vieau, D., Chartrel, N., Boutelet, I., Galas, L., Fournier, A., Lihrmann, I., Vaudry, H. Endocrinology (2002) [Pubmed]
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