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Gene Review:

PTDSS2 - phosphatidylserine synthase 2

Homo sapiens

Synonyms: PSS-2, PSS2, Phosphatidylserine synthase 2, PtdSer synthase 2, Serine-exchange enzyme II

Grandmaison, P.A. et al., Tostivint, H. et al., Tostivint, H. et al., Vance, J.E. et al., Dygas, A. et al.

Vance, Vance, Dygas, Barańska, Santella,

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High impact information on PTDSS2

In situ hybridization studies indicate differential expression of the PSS1 and PSS2 genes in the septum, the lateral part of the pallium, the amygdaloid complex, the posterior nuclei of the thalamus, the ventral hypothalamic nucleus, the torus semicircularis and the optic tectum [1].
Finally, the two base-exchange enzymes, phosphatidylserine synthase-1 and phosphatidylserine synthase-2, that synthesize phosphatidylserine in mammalian cells are also discussed [2].
Moreover, a normal level of expression of PSS1 and/or PSS2 is not required for generating the pool of PtdSer externalized during apoptosis [3].
Phosphatidylserine (PtdSer) is made in mammalian cells by two PtdSer synthases, PSS1 and PSS2 [3].
We induced apoptosis with staurosporine in four Chinese hamster ovary (CHO) cell lines that are deficient in PSS1 and/or PSS2 to determine if PtdSer generated by either of these enzymes is required for externalization on the cell surface during apoptosis [3].

Anatomical context of PTDSS2

It was found that the levels of PSS1 and PSS2 transcripts were higher in immature and mature oocytes, respectively [4].
In all cell lines, regardless of their content of PSS1 and/or PSS2, apoptosis occurred to approximately the same extent, and within approximately the same time frame, as in parental CHO-K1 cells [3].

Analytical, diagnostic and therapeutic context of PTDSS2

The distribution of PSS1- and PSS2-derived peptides has been investigated by immunohistochemistry using two antisera directed against SS1 and the sequence 54-66 of PSS2 (PSS2(54-66)), respectively [5].

References

Occurrence of two somatostatin variants in the frog brain: characterization of the cDNAs, distribution of the mRNAs, and receptor-binding affinities of the peptides. Tostivint, H., Lihrmann, I., Bucharles, C., Vieau, D., Coulouarn, Y., Fournier, A., Conlon, J.M., Vaudry, H. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
Phospholipid biosynthesis in mammalian cells. Vance, J.E., Vance, D.E. Biochem. Cell Biol. (2004) [Pubmed]
Externalization of phosphatidylserine during apoptosis does not specifically require either isoform of phosphatidylserine synthase. Grandmaison, P.A., Nanowski, T.S., Vance, J.E. Biochim. Biophys. Acta (2004) [Pubmed]
Ca2+-dependent phosphatidylserine synthesis in immature and mature starfish oocytes. Dygas, A., Barańska, J., Santella, L. Acta Biochim. Pol. (2003) [Pubmed]
Expression and processing of the [Pro(2),Met(13)]somatostatin-14 precursor in the intermediate lobe of the frog pituitary. Tostivint, H., Vieau, D., Chartrel, N., Boutelet, I., Galas, L., Fournier, A., Lihrmann, I., Vaudry, H. Endocrinology (2002) [Pubmed]

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