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Gene Review

Ptdss2  -  phosphatidylserine synthase 2

Mus musculus

Synonyms: AI481134, AI988017, PSS-2, PSS2, Phosphatidylserine synthase 2, ...
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Disease relevance of Ptdss2

  • In both M.9.1.1 and hepatoma cells transfected with PSS2 cDNA the rate of synthesis of PtdSer and PtdSer-derived PtdEtn did not exceed that in parental CHO cells or control McArdle cells respectively, in contrast to cells expressing similar levels of murine PSS1 [1].

High impact information on Ptdss2

  • As judged by Northern blots, the expression of Pss1 was not up-regulated in Pss2-deficient cells and tissues [2].
  • We conclude that Pss2 is responsible for the majority of serine exchange activity in in vitro assays, but a deficiency in this enzyme does not cause perturbations in phospholipid content or severe developmental abnormalities [2].
  • The ability of testis extracts from Pss2-deficient mice to catalyze serine exchange was reduced by more than 95%; reductions of approximately 90% were noted in the brain and liver [2].
  • Testis weight was reduced in Pss2-deficient mice, and some of the male mice were infertile [2].
  • Histologic studies of Pss2-deficient mice revealed very high levels of beta-galactosidase expression in Sertoli cells of the testis and high levels of expression in brown fat, neurons, and myometrium [2].

Biological context of Ptdss2


Anatomical context of Ptdss2


Associations of Ptdss2 with chemical compounds


Analytical, diagnostic and therapeutic context of Ptdss2

  • According to reverse transcriptase-mediated polymerase chain reaction, PSS1 and PSS2 mRNAs were expressed in all murine tissues examined [3].
  • Unexpectedly, using immunoblotting experiments, we found that (i) PSS2 of CHO-K1 cells is present only in MAM and (ii) PSS2 is restricted to MAM of McArdle cells expressing recombinant PSS2 [5].


  1. Cloning and expression of murine liver phosphatidylserine synthase (PSS)-2: differential regulation of phospholipid metabolism by PSS1 and PSS2. Stone, S.J., Vance, J.E. Biochem. J. (1999) [Pubmed]
  2. Defining the importance of phosphatidylserine synthase 2 in mice. Bergo, M.O., Gavino, B.J., Steenbergen, R., Sturbois, B., Parlow, A.F., Sanan, D.A., Skarnes, W.C., Vance, J.E., Young, S.G. J. Biol. Chem. (2002) [Pubmed]
  3. Structure and expression of the murine phosphatidylserine synthase-1 gene. Sturbois-Balcerzak, B., Stone, S.J., Sreenivas, A., Vance, J.E. J. Biol. Chem. (2001) [Pubmed]
  4. Phospholipid homeostasis in phosphatidylserine synthase-2-deficient mice. Steenbergen, R., Nanowski, T.S., Nelson, R., Young, S.G., Vance, J.E. Biochim. Biophys. Acta (2006) [Pubmed]
  5. Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes. Stone, S.J., Vance, J.E. J. Biol. Chem. (2000) [Pubmed]
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