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Gene Review:

HA1 - H(+)-ATPase 1

Arabidopsis thaliana

Synonyms: AHA1, F19F24.16, F19F24_16, OPEN STOMATA 2, OST2, ...

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High impact information on AHA1

We also demonstrate that 5'-AMP inhibits the association of 14-3-3 proteins with the C-terminal domain of the H(+)-ATPase in an overlay assay as well as the 14-3-3-dependent stimulation of the Arabidopsis thaliana H(+)-ATPase AHA1 isoform expressed in yeast membranes [1].
In addition, AHA2 had a slightly lower apparent affinity for H+ and seemed to be more susceptible to activation by lysophosphatidylcholine than did AHA1 and AHA3 [2].
In the 3'-untranslated sequence of AHA1 and AHA2 but not AHA3, there is a 65-bp region of 85% identity and a second shorter region of 16-bp identity harboring an unusual putative poly(A) addition signal (dTTTGAAGAAACAAGGC) [3].
A novel interaction partner for the C-terminus of Arabidopsis thaliana plasma membrane H+-ATPase (AHA1 isoform): site and mechanism of action on H+-ATPase activity differ from those of 14-3-3 proteins [4].
Comparison of the aha9 predicted amino acid sequence with those of aha1, 2 and 3 and analogous genes from other species indicated the existence of at least two aha gene subfamilies whose divergence precedes that of the Nicotiana and Arabidopsis species [5].

Associations of AHA1 with chemical compounds

Proton pump and auxin effect in Arabidopsis thaliana leaves during the development [6].

Analytical, diagnostic and therapeutic context of AHA1

A Trp-874-Phe substitution in AHA1 was produced gy site-directed mutagenesis [7].
However, mass peptide fingerprinting identified AHA1 and 2 with the highest score, and their presence could be confirmed by MS/MS [8].

References

Adenosine 5'-monophosphate inhibits the association of 14-3-3 proteins with the plant plasma membrane H(+)-ATPase. Camoni, L., Visconti, S., Marra, M., Aducci, P. J. Biol. Chem. (2001) [Pubmed]
Functional comparisons between plant plasma membrane H(+)-ATPase isoforms expressed in yeast. Palmgren, M.G., Christensen, G. J. Biol. Chem. (1994) [Pubmed]
The Arabidopsis thaliana plasma membrane H(+)-ATPase multigene family. Genomic sequence and expression of a third isoform. Harper, J.F., Manney, L., DeWitt, N.D., Yoo, M.H., Sussman, M.R. J. Biol. Chem. (1990) [Pubmed]
A novel interaction partner for the C-terminus of Arabidopsis thaliana plasma membrane H+-ATPase (AHA1 isoform): site and mechanism of action on H+-ATPase activity differ from those of 14-3-3 proteins. Morandini, P., Valera, M., Albumi, C., Bonza, M.C., Giacometti, S., Ravera, G., Murgia, I., Soave, C., De Michelis, M.I. Plant J. (2002) [Pubmed]
Identification of an Arabidopsis thaliana gene encoding a plasma membrane H(+)-ATPase whose expression is restricted to anther tissue. Houlné, G., Boutry, M. Plant J. (1994) [Pubmed]
Proton pump and auxin effect in Arabidopsis thaliana leaves during the development. Bellamine, J., Greppin, H. Biochem. Mol. Biol. Int. (1996) [Pubmed]
Modified plant plasma membrane H(+)-ATPase with improved transport coupling efficiency identified by mutant selection in yeast. Baunsgaard, L., Venema, K., Axelsen, K.B., Villalba, J.M., Welling, A., Wollenweber, B., Palmgren, M.G. Plant J. (1996) [Pubmed]
Plasma membrane H(+)-ATPase and 14-3-3 isoforms of Arabidopsis leaves: evidence for isoform specificity in the 14-3-3/H(+)-ATPase interaction. Alsterfjord, M., Sehnke, P.C., Arkell, A., Larsson, H., Svennelid, F., Rosenquist, M., Ferl, R.J., Sommarin, M., Larsson, C. Plant Cell Physiol. (2004) [Pubmed]

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