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HMA4  -  putative cadmium/zinc-transporting ATPase...

Arabidopsis thaliana

Synonyms: ARABIDOPSIS HEAVY METAL ATPASE 4, ATHMA4, T20K24.12, T20K24_12, heavy metal atpase 4
 
 
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High impact information on HMA4

  • Three of these transporters, HMA2, HMA3, and HMA4, are closely related to each other and are most similar in sequence to the divalent heavy metal cation transporters of prokaryotes [1].
  • The organ specificity of AtHMA4 was analysed in Arabidopsis and showed that AtHMA4 was expressed in a range of tissues with highest expression in roots [2].
  • It has been previously shown, by heterologous expression and the study of AtHMA4 knockout or overexpressing lines in Arabidopsis , that AtHMA4 is implicated in zinc homeostasis and cadmium tolerance [3].
  • Mutagenesis of the cysteine and glutamate residues from the N-ter degenerated heavy metal binding domain impaired the function of AtHMA4 [3].
  • Overexpression of AtHMA4 enhances root-to-shoot translocation of zinc and cadmium and plant metal tolerance [4].
 

Anatomical context of HMA4

  • Here, we demonstrate that AtHMA4 is localized at the plasma membrane and expressed in tissues surrounding the root vascular vessels [4].
 

Associations of HMA4 with chemical compounds

  • In contrast, the AtHMA4 overexpressing lines displayed an increase in the zinc and cadmium shoot content [4].
  • Our data indicate that HMA4 could be involved in Cd(2+) transport and possibly in the Cd hyperaccumulation character [5].
 

Other interactions of HMA4

  • HMA2promoter- and HMA4promoter-reporter gene constructs provide evidence that HMA2 and HMA4 expression is predominantly in the vascular tissues of roots, stems, and leaves [1].

References

  1. P-type ATPase heavy metal transporters with roles in essential zinc homeostasis in Arabidopsis. Hussain, D., Haydon, M.J., Wang, Y., Wong, E., Sherson, S.M., Young, J., Camakaris, J., Harper, J.F., Cobbett, C.S. Plant Cell (2004) [Pubmed]
  2. Functional expression of AtHMA4, a P1B-type ATPase of the Zn/Co/Cd/Pb subclass. Mills, R.F., Krijger, G.C., Baccarini, P.J., Hall, J.L., Williams, L.E. Plant J. (2003) [Pubmed]
  3. Heavy metal transport by AtHMA4 involves the N-terminal degenerated metal binding domain and the C-terminal His11 stretch. Verret, F., Gravot, A., Auroy, P., Preveral, S., Forestier, C., Vavasseur, A., Richaud, P. FEBS Lett. (2005) [Pubmed]
  4. Overexpression of AtHMA4 enhances root-to-shoot translocation of zinc and cadmium and plant metal tolerance. Verret, F., Gravot, A., Auroy, P., Leonhardt, N., David, P., Nussaume, L., Vavasseur, A., Richaud, P. FEBS Lett. (2004) [Pubmed]
  5. A novel CPx-ATPase from the cadmium hyperaccumulator Thlaspi caerulescens. Bernard, C., Roosens, N., Czernic, P., Lebrun, M., Verbruggen, N. FEBS Lett. (2004) [Pubmed]
 
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