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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Organ Specificity

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Disease relevance of Organ Specificity


High impact information on Organ Specificity


Chemical compound and disease context of Organ Specificity


Biological context of Organ Specificity


Anatomical context of Organ Specificity

  • Since the G3 domain of cartilage proteoglycan aggrecan with the p135 sequence is "lost" during the normal metabolic turnover of cartilage proteoglycan or in pathologic conditions, an antigenoriented T cell migration into joints of presensitized (susceptible) individuals may contribute to the organ-specificity of RA [16].
  • According to these results, TSI might represent an autoantibody to the membranes associated with the TSH receptor of the target tissues without a strict organ specificity [17].
  • Investigating the organ specificity of PAP, we found that some cross-reacting acid phosphatase activity could be so measured in human kidney, leukocytes, and platelets, all of which probably contribute to the circulating "prostatic" acid phosphatase that normally is present in serum [18].
  • The organ specificity in binding suggests that covalent binding by lung microsomes may be related to the mechanism of 3MI-induced lung injury [19].
  • Regarding CA IV, the results lead to the conclusion that omeprazole selectively inhibits gastric mucosa CA IV and does not modify the activity of the same isozyme from the kidney and lung, indicating organ specificity [20].

Associations of Organ Specificity with chemical compounds


Gene context of Organ Specificity

  • Their involvement in conferring substrate dependency and organ specificity of PORA import was analyzed in intact Arabidopsis seedlings of wild type and the three mutants ppi3, ppi1 and ppi2 that are deficient in atToc34, atToc33, a closely related isoform of atToc34, and atToc159 [26].
  • The results suggest a different pattern for the involvement of the ras genes in 1-nitropyrene-caused carcinogenesis, and also underlines the differences in the organ specificity of chemical carcinogens in humans and in experimental animals [27].
  • Further studies are warranted to elucidate the function of this SULT1A1 polymorphism with regard to organ specificity, gene-environment interactions, and the gender-related difference we observed [28].
  • Biochemical studies on the structures and the organ specificities of several mucin core proteins (MUC1-MUC7) have been reported during the past several years [29].
  • The organ specificity of AtHMA4 was analysed in Arabidopsis and showed that AtHMA4 was expressed in a range of tissues with highest expression in roots [30].

Analytical, diagnostic and therapeutic context of Organ Specificity


  1. Inhibition of carcinogenesis by retinoids. Moon, R.C., McCormick, D.L., Mehta, R.G. Cancer Res. (1983) [Pubmed]
  2. Interaction of ligand-receptor system between stromal-cell-derived factor-1 and CXC chemokine receptor 4 in human prostate cancer: a possible predictor of metastasis. Mochizuki, H., Matsubara, A., Teishima, J., Mutaguchi, K., Yasumoto, H., Dahiya, R., Usui, T., Kamiya, K. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  3. Anti-cytoplasmic autoantibodies reactive with epithelial cells of the salivary gland in sera from patients with Sjögren's syndrome: their disease- and organ-specificities. Sakamoto, M., Miyazawa, M., Mori, S., Fujisawa, R. J. Oral Pathol. Med. (1999) [Pubmed]
  4. Melanin potentiates kanamycin-induced inhibition of collagen biosynthesis in human skin fibroblasts. Wrześniok, D., Buszman, E., Karna, E., Pałka, J. Die Pharmazie. (2005) [Pubmed]
  5. Comparison of lesions induced in the Syrian golden hamster by diethylnitrosamine, dimethylhydrazine, and dibutylnitrosamine: influence of subsequent butylated hydroxyanisole treatment. Moore, M.A., Thamavit, W., Ito, N. J. Natl. Cancer Inst. (1987) [Pubmed]
  6. Substrate-dependent and organ-specific chloroplast protein import in planta. Kim, C., Apel, K. Plant Cell (2004) [Pubmed]
  7. Expression patterns of myb genes from Antirrhinum flowers. Jackson, D., Culianez-Macia, F., Prescott, A.G., Roberts, K., Martin, C. Plant Cell (1991) [Pubmed]
  8. Extracellular matrix promotes mammary epithelial growth and differentiation in vitro. Wicha, M.S., Lowrie, G., Kohn, E., Bagavandoss, P., Mahn, T. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  9. Arabidopsis CYP735A1 and CYP735A2 encode cytokinin hydroxylases that catalyze the biosynthesis of trans-Zeatin. Takei, K., Yamaya, T., Sakakibara, H. J. Biol. Chem. (2004) [Pubmed]
  10. Allopurinol toxicity: its toxic organ-specificity between the liver and the kidney in the rat. Suzuki, Y., Sudo, J., Tanabe, T. The Journal of toxicological sciences. (1984) [Pubmed]
  11. Polyomavirus DNA replication in the pancreas and in a transformed pancreas cell line has distinct enhancer requirements. Rochford, R., Villarreal, L.P. J. Virol. (1991) [Pubmed]
  12. Far-upstream elements are dispensable for tissue-specific proenkephalin expression using a Cre-mediated knock-in strategy. Le, Y., Gagneten, S., Larson, T., Santha, E., Dobi, A., v Agoston, D., Sauer, B. J. Neurochem. (2003) [Pubmed]
  13. Organ-specific expression of the lacZ gene controlled by the opsin promoter after intravenous gene administration in adult mice. Zhu, C., Zhang, Y., Zhang, Y.F., Yi Li, J., Boado, R.J., Pardridge, W.M. The journal of gene medicine. (2004) [Pubmed]
  14. Nucleotide sequence of a tobacco cDNA encoding plastidic glutamine synthetase and light inducibility, organ specificity and diurnal rhythmicity in the expression of the corresponding genes of tobacco and tomato. Becker, T.W., Caboche, M., Carrayol, E., Hirel, B. Plant Mol. Biol. (1992) [Pubmed]
  15. Position- and base pair-specific comparison of p53 mutation spectra in human tumors: elucidation of relationships between organs for cancer etiology. Lutz, W.K., Fekete, T., Vamvakas, S. Environ. Health Perspect. (1998) [Pubmed]
  16. Induction of arthritis in SCID mice by T cells specific for the "shared epitope" sequence in the G3 domain of human cartilage proteoglycan. Hanyecz, A., Bárdos, T., Berlo, S.E., Buzás, E., Nesterovitch, A.B., Mikecz, K., Glant, T.T. Arthritis Rheum. (2003) [Pubmed]
  17. Interaction between thyroid-stimulating immunoglobulins and thyrotropin receptors in fat cell membranes. Kishihara, M., Nakao, Y., Baba, Y., Matsukura, S., Kuma, K., Fujita, T. J. Clin. Endocrinol. Metab. (1979) [Pubmed]
  18. Development and evaluation of a new solid-phase direct immunoenzyme assay for prostatic acid phosphatase. Gericke, K., Kohse, K.P., Pfleiderer, G., Flüchter, S.H., Bichler, K.H. Clin. Chem. (1982) [Pubmed]
  19. In vitro covalent binding of 3-[14C]methylindole metabolites in goat tissues. Bray, T.M., Carlson, J.R., Nocerini, M.R. Proc. Soc. Exp. Biol. Med. (1984) [Pubmed]
  20. Omeprazole has a dual mechanism of action: it inhibits both H(+)K(+)ATPase and gastric mucosa carbonic anhydrase enzyme in humans (in vitro and in vivo experiments). Puscas, I., Coltau, M., Baican, M., Domuta, G. J. Pharmacol. Exp. Ther. (1999) [Pubmed]
  21. Organ specificity of glucocorticoid-sensitive tyrosine aminotransferase. Separation from aspartate aminotransferase isoenzymes. Hargrove, J.L., Mackin, R.B. J. Biol. Chem. (1984) [Pubmed]
  22. The chemopreventive agent oltipraz possesses potent antiangiogenic activity in vitro, ex vivo, and in vivo and inhibits tumor xenograft growth. Ruggeri, B.A., Robinson, C., Angeles, T., Wilkinson, J., Clapper, M.L. Clin. Cancer Res. (2002) [Pubmed]
  23. Formation of N-7-(2-carbamoyl-2-hydroxyethyl)guanine in DNA of the mouse and the rat following intraperitoneal administration of [14C]acrylamide. Segerbäck, D., Calleman, C.J., Schroeder, J.L., Costa, L.G., Faustman, E.M. Carcinogenesis (1995) [Pubmed]
  24. 1-C-glucuronidation of N-nitrosodiethylamine and N-nitrosomethyl-n-pentylamine in vivo and in primary hepatocytes from rats pretreated with inducers. Wiench, K., Frei, E., Schroth, P., Wiessler, M. Carcinogenesis (1992) [Pubmed]
  25. N-acetylbenzidine and N,N'-diacetylbenzidine formation by rat and human liver slices exposed to benzidine. Lakshmi, V.M., Bell, D.A., Watson, M.A., Zenser, T.V., Davis, B.B. Carcinogenesis (1995) [Pubmed]
  26. Multiplicity of different cell- and organ-specific import routes for the NADPH-protochlorophyllide oxidoreductases A and B in plastids of Arabidopsis seedlings. Kim, C., Ham, H., Apel, K. Plant J. (2005) [Pubmed]
  27. 1-Nitropyrene induces elevated expression of oncogenes and tumor suppressor genes 24 hours after treatment in CBA/Ca mice. Ember, I., Pusztai, Z., Gyöngyi, Z., Kiss, I. Anticancer Res. (2000) [Pubmed]
  28. Sulfotransferase 1A1 (SULT1A1) polymorphism and bladder cancer risk: a case-control study. Zheng, L., Wang, Y., Schabath, M.B., Grossman, H.B., Wu, X. Cancer Lett. (2003) [Pubmed]
  29. Expression of mucin antigens in human cancers and its relationship with malignancy potential. Yonezawa, S., Sato, E. Pathol. Int. (1997) [Pubmed]
  30. Functional expression of AtHMA4, a P1B-type ATPase of the Zn/Co/Cd/Pb subclass. Mills, R.F., Krijger, G.C., Baccarini, P.J., Hall, J.L., Williams, L.E. Plant J. (2003) [Pubmed]
  31. Mouse seminal vesicle secretory protein of 99 amino acids (MSVSP99): characterization and hormonal and developmental regulation. Morel, L., Brochard, D., Manin, M., Simon, A.M., Jean, C., Veyssiere, G. J. Androl. (2001) [Pubmed]
  32. Mutation induction by N-propyl-N-nitrosourea in eight MutaMouse organs. Hara, T., Hirano, K., Hirano, N., Tamura, H., Sui, H., Shibuya, T., Hyogo, A., Hirashio, T., Tokai, H., Yamashita, Y., Kura, K. Mutat. Res. (1999) [Pubmed]
  33. DNA damage and DNA adduct formation in rat tissues following oral administration of acrylamide. Manière, I., Godard, T., Doerge, D.R., Churchwell, M.I., Guffroy, M., Laurentie, M., Poul, J.M. Mutat. Res. (2005) [Pubmed]
  34. Human anti-hyaluronic acid antibodies: is it possible? Micheels, P. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. (2001) [Pubmed]
  35. Homing kinetics of indium-111 labelled bacteria: detection of organ specificities as revealed by scintigraphy. Friedrich, E.A., Lehmann, V., Süss, R., Sinn, H. International journal of nuclear medicine and biology. (1982) [Pubmed]
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