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Gene Review:

Pth2r - parathyroid hormone 2 receptor

Rattus norvegicus

Synonyms: PTH2 receptor, Parathyroid hormone 2 receptor, Pthr2

Usdin, T.B. et al., Sugimura, Y. et al., Ross, G. et al.

Usdin, Bonner, Harta, Mezey,

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High impact information on Pthr2

These results suggest that an inhibition of endogenous NO production unmasks a profound negative inotropic effect of TIP39 that is mediated by an activation of the PTH2 receptor [1].
The PTH2 receptor is highly expressed in the hypothalamus, suggesting a role in the modulation of neuroendocrinological functions [2].
The PTH2 receptor is a recently identified G protein-coupled receptor activated by PTH [3].
We previously demonstrated using Northern blots that expression of PTH2 receptor messenger RNA was greatest within the brain and occurred at lower levels in pancreas, testis, and placenta [3].
PTH2 receptor messenger RNA is abundantly expressed in arterial and cardiac endothelium and at lower levels in vascular smooth muscle [3].

Regulatory relationships of Pthr2

Tuberoinfundibular peptide of 39 residues (TIP39) is a recently discovered neuropeptide identified on the basis of its ability to activate the PTH2 receptor, and it is thought to be the brain PTH2 receptor's endogenous ligand [2].

Analytical, diagnostic and therapeutic context of Pthr2

We have now obtained a complementary DNA encoding the rat PTH2 receptor and used it to study the distribution of the PTH2 receptor using in situ hybridization histochemistry [3].

References

Tuberoinfundibular peptide of 39 residues: a new mediator of cardiac function via nitric oxide production in the rat heart. Ross, G., Engel, P., Abdallah, Y., Kummer, W., Schluter, K.D. Endocrinology (2005) [Pubmed]
Centrally administered tuberoinfundibular peptide of 39 residues inhibits arginine vasopressin release in conscious rats. Sugimura, Y., Murase, T., Ishizaki, S., Tachikawa, K., Arima, H., Miura, Y., Usdin, T.B., Oiso, Y. Endocrinology (2003) [Pubmed]
Distribution of parathyroid hormone-2 receptor messenger ribonucleic acid in rat. Usdin, T.B., Bonner, T.I., Harta, G., Mezey, E. Endocrinology (1996) [Pubmed]

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PTH2R	Bos taurus
PTH2R	Canis lupus familiaris
pth2r	Danio rerio
si:dkeyp-4h4.1	Danio rerio
PTH2R	Homo sapiens
PTH2R	Macaca mulatta
Pth2r	Mus musculus
PTH2R	Pan troglodytes
pth2r	Xenopus (Silurana) tropicalis

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