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Gene Review

PTH2R  -  parathyroid hormone 2 receptor

Homo sapiens

Synonyms: PTH2 receptor, PTHR2, Parathyroid hormone 2 receptor
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Disease relevance of PTHR2


High impact information on PTHR2


Biological context of PTHR2


Anatomical context of PTHR2


Physical interactions of PTHR2

  • This method is useful for measurement of agonist and antagonist radioligand binding at the PTH-1 receptor and binding of [125I]PTH(1-34) at the PTH-2 receptor [12].

Regulatory relationships of PTHR2


Other interactions of PTHR2

  • Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor [7].
  • Recently, a new G protein-coupled receptor with substantial implications for vascular function--the PTH2 receptor (PTH2-R)--has been identified, however, expression and distribution in humans and a possible regulation has not yet been studied [1].
  • In fact there is more than one receptor - the PTH2 receptor and a putative carboxy-terminal PTH receptor [14].
  • In particular, the [Bpa2]- and [Bpa4]-substituted analogs selectively antagonized and preferentially cross-linked to the PTH-1 receptor and PTH-2 receptor, respectively [15].

Analytical, diagnostic and therapeutic context of PTHR2


  1. The parathyroid hormone-2 receptor is expressed on human leukocytes and down-regulated in hyperparathyroidism. Seeliger, S., Hausberg, M., Eue, I., Usdin, T., Rahn, K.H., Kosch, M. Clin. Nephrol. (2003) [Pubmed]
  2. New members of the parathyroid hormone/parathyroid hormone receptor family: the parathyroid hormone 2 receptor and tuberoinfundibular peptide of 39 residues. Usdin, T.B., Wang, T., Hoare, S.R., Mezey, E., Palkovits, M. Frontiers in neuroendocrinology. (2000) [Pubmed]
  3. TIP39: a new neuropeptide and PTH2-receptor agonist from hypothalamus. Usdin, T.B., Hoare, S.R., Wang, T., Mezey, E., Kowalak, J.A. Nat. Neurosci. (1999) [Pubmed]
  4. Structure of tuberoinfundibular peptide of 39 residues. Piserchio, A., Usdin, T., Mierke, D.F. J. Biol. Chem. (2000) [Pubmed]
  5. A G protein-coupled receptor from zebrafish is activated by human parathyroid hormone and not by human or teleost parathyroid hormone-related peptide. Implications for the evolutionary conservation of calcium-regulating peptide hormones. Rubin, D.A., Hellman, P., Zon, L.I., Lobb, C.J., Bergwitz, C., Jüppner, H. J. Biol. Chem. (1999) [Pubmed]
  6. Converting parathyroid hormone-related peptide (PTHrP) into a potent PTH-2 receptor agonist. Gardella, T.J., Luck, M.D., Jensen, G.S., Usdin, T.B., Jüppner, H. J. Biol. Chem. (1996) [Pubmed]
  7. Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor. Usdin, T.B., Gruber, C., Bonner, T.I. J. Biol. Chem. (1995) [Pubmed]
  8. Strong linkage on 2q33.3 to familial early-onset generalized osteoarthritis and a consideration of two positional candidate genes. Meulenbelt, I., Min, J.L., van Duijn, C.M., Kloppenburg, M., Breedveld, F.C., Slagboom, P.E. Eur. J. Hum. Genet. (2006) [Pubmed]
  9. The human PTH2 receptor: binding and signal transduction properties of the stably expressed recombinant receptor. Behar, V., Pines, M., Nakamoto, C., Greenberg, Z., Bisello, A., Stueckle, S.M., Bessalle, R., Usdin, T.B., Chorev, M., Rosenblatt, M., Suva, L.J. Endocrinology (1996) [Pubmed]
  10. Assignment of the human PTH2 receptor gene (PTHR2) to chromosome 2q33 by fluorescence in situ hybridization. Usdin, T.B., Modi, W., Bonner, T.I. Genomics (1996) [Pubmed]
  11. Distribution of the parathyroid hormone 2 receptor in rat: immunolocalization reveals expression by several endocrine cells. Usdin, T.B., Hilton, J., Vertesi, T., Harta, G., Segre, G., Mezey, E. Endocrinology (1999) [Pubmed]
  12. Quantitative cell membrane-based radioligand binding assays for parathyroid hormone receptors. Hoare, S.R., Usdin, T.B. Journal of pharmacological and toxicological methods. (1999) [Pubmed]
  13. Molecular mechanisms of ligand recognition by parathyroid hormone 1 (PTH1) and PTH2 receptors. Hoare, S.R., Usdin, T.B. Curr. Pharm. Des. (2001) [Pubmed]
  14. Harnessing the parathyroids to create stronger bones. Silver, J., Bushinsky, D. Curr. Opin. Nephrol. Hypertens. (2004) [Pubmed]
  15. Studies of the N-terminal region of a parathyroid hormone-related peptide (1-36) analog: receptor subtype-selective agonists, antagonists, and photochemical cross-linking agents. Carter, P.H., Jüppner, H., Gardella, T.J. Endocrinology (1999) [Pubmed]
  16. Postnatal development and gender-dependent expression of TIP39 in the rat brain. Dobolyi, A., Wang, J., Irwin, S., Usdin, T.B. J. Comp. Neurol. (2006) [Pubmed]
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