The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

P5CS1  -  delta1-pyrroline-5-carboxylate synthase 1

Arabidopsis thaliana

Synonyms: ATP5CS, T5I7.10, T5I7_10
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of P5CS1


High impact information on P5CS1

  • Overexpression of Gm-CaM4 in Arabidopsis up-regulates the transcription rate of AtMYB2-regulated genes, including the proline-synthesizing enzyme P5CS1 (Delta1-pyrroline-5-carboxylate synthetase-1), which confers salt tolerance by facilitating proline accumulation [2].
  • However, inhibition of protein synthesis by cycloheximide prevents the induction of AtP5CS2 mRNA accumulation, and blocks further increase of AtP5CS1 mRNA levels during the second, slow phase of salt-induction [1].
  • Induction of AtP5CS1 mRNA accumulation in salt-treated seedlings involves an immediate early transcriptional response regulated by ABA signalling that is not inhibited by cycloheximide, but abolished by the deficiency of ABA biosynthesis in the aba1 Arabidopsis mutant [1].
  • Gene AtP5CS1 mapped to chromosome 2-78.5 is expressed in most plant organs, but silent in dividing cells [1].
  • Regulation of P5CS1 expression thus appears to play a principal role in controlling proline accumulation stimulated by ABA and salt stress in Arabidopsis [3].

Biological context of P5CS1


Associations of P5CS1 with chemical compounds

  • Delta(1)-Pyrroline-5-carboxylate synthetase 1 (P5CS1) is the rate-limiting enzyme in the biosynthesis of proline by Arabidopsis thaliana [4].


  1. Differential expression of two P5CS genes controlling proline accumulation during salt-stress requires ABA and is regulated by ABA1, ABI1 and AXR2 in Arabidopsis. Strizhov, N., Abrahám, E., Okrész, L., Blickling, S., Zilberstein, A., Schell, J., Koncz, C., Szabados, L. Plant J. (1997) [Pubmed]
  2. Direct interaction of a divergent CaM isoform and the transcription factor, MYB2, enhances salt tolerance in arabidopsis. Yoo, J.H., Park, C.Y., Kim, J.C., Heo, W.D., Cheong, M.S., Park, H.C., Kim, M.C., Moon, B.C., Choi, M.S., Kang, Y.H., Lee, J.H., Kim, H.S., Lee, S.M., Yoon, H.W., Lim, C.O., Yun, D.J., Lee, S.Y., Chung, W.S., Cho, M.J. J. Biol. Chem. (2005) [Pubmed]
  3. Light-dependent induction of proline biosynthesis by abscisic acid and salt stress is inhibited by brassinosteroid in Arabidopsis. Abrahám, E., Rigó, G., Székely, G., Nagy, R., Koncz, C., Szabados, L. Plant Mol. Biol. (2003) [Pubmed]
  4. Stress-responsive and developmental regulation of Delta(1)-pyrroline-5-carboxylate synthetase 1 (P5CS1) gene expression in Arabidopsis thaliana. Yoshiba, Y., Nanjo, T., Miura, S., Yamaguchi-Shinozaki, K., Shinozaki, K. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  5. Proline accumulation and AtP5CS2 gene activation are induced by plant-pathogen incompatible interactions in Arabidopsis. Fabro, G., Kovács, I., Pavet, V., Szabados, L., Alvarez, M.E. Mol. Plant Microbe Interact. (2004) [Pubmed]
WikiGenes - Universities