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Gene Review

ABA1  -  zeaxanthin epoxidase

Arabidopsis thaliana

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Disease relevance of ABA1


High impact information on ABA1


Biological context of ABA1

  • Regulation of osmotic stress-responsive gene expression by the LOS6/ABA1 locus in Arabidopsis [6].
  • Here we report the isolation, characterization, and cloning of a mutation, los6, which diminished osmotic stress activation of a reporter gene [6].
  • By contrast, ABA deficiency as conditioned by the mutations in the ABA1 and ABA2 genes, which encode enzymes involved in ABA biosynthesis, resulted in upregulation of basal and induced transcription from JA-ethylene responsive defense genes [7].
  • The high levels of zeaxanthin in npq2 affected the kinetics of induction and relaxation but not the extent of nonphotochemical quenching [8].
  • ABA-deficient mutants, however, display a stunted phenotype even under well-watered conditions and high relative humidity, which suggests that growth promotion may also be one of the roles of endogenous ABA [9].

Anatomical context of ABA1

  • Experiments on purified thylakoid membranes from all three mutants showed that the major source of the difference between the npq2 and wild-type preparations was a change in pigment to protein interactions, which can explain the lower chlorophyll fluorescence yield in the npq2 samples [10].

Associations of ABA1 with chemical compounds


Other interactions of ABA1


Analytical, diagnostic and therapeutic context of ABA1

  • Complementation tests with different ABA-deficient mutants indicated that sre2-1 and sre2-2 mutants were allelic to aao3-1, and therefore they were renamed as aao3-2 and aao3-3, respectively [19].
  • An ABA immunoassay supported this hypothesis: ABA-entrained plants showed a transient increase in endogenous ABA level from 220 to 250 pmol g-1 fresh mass at 1-2 h of the training period, whereas ABA-deficient (aba2) mutants did not [20].


  1. Molecular identification of zeaxanthin epoxidase of Nicotiana plumbaginifolia, a gene involved in abscisic acid biosynthesis and corresponding to the ABA locus of Arabidopsis thaliana. Marin, E., Nussaume, L., Quesada, A., Gonneau, M., Sotta, B., Hugueney, P., Frey, A., Marion-Poll, A. EMBO J. (1996) [Pubmed]
  2. HOS5-a negative regulator of osmotic stress-induced gene expression in Arabidopsis thaliana. Xiong, L., Ishitani, M., Lee, H., Zhu, J.K. Plant J. (1999) [Pubmed]
  3. Characterization of an Arabidopsis thaliana mutant that has a defect in ABA accumulation: ABA-dependent and ABA-independent accumulation of free amino acids during dehydration. Nambara, E., Kawaide, H., Kamiya, Y., Naito, S. Plant Cell Physiol. (1998) [Pubmed]
  4. Analysis of Arabidopsis glucose insensitive mutants, gin5 and gin6, reveals a central role of the plant hormone ABA in the regulation of plant vegetative development by sugar. Arenas-Huertero, F., Arroyo, A., Zhou, L., Sheen, J., León, P. Genes Dev. (2000) [Pubmed]
  5. Dissecting the beta-aminobutyric acid-induced priming phenomenon in Arabidopsis. Ton, J., Jakab, G., Toquin, V., Flors, V., Iavicoli, A., Maeder, M.N., Métraux, J.P., Mauch-Mani, B. Plant Cell (2005) [Pubmed]
  6. Regulation of osmotic stress-responsive gene expression by the LOS6/ABA1 locus in Arabidopsis. Xiong, L., Lee, H., Ishitani, M., Zhu, J.K. J. Biol. Chem. (2002) [Pubmed]
  7. Antagonistic interaction between abscisic acid and jasmonate-ethylene signaling pathways modulates defense gene expression and disease resistance in Arabidopsis. Anderson, J.P., Badruzsaufari, E., Schenk, P.M., Manners, J.M., Desmond, O.J., Ehlert, C., Maclean, D.J., Ebert, P.R., Kazan, K. Plant Cell (2004) [Pubmed]
  8. Arabidopsis mutants define a central role for the xanthophyll cycle in the regulation of photosynthetic energy conversion. Niyogi, K.K., Grossman, A.R., Björkman, O. Plant Cell (1998) [Pubmed]
  9. A mutational analysis of the ABA1 gene of Arabidopsis thaliana highlights the involvement of ABA in vegetative development. Barrero, J.M., Piqueras, P., González-Guzmán, M., Serrano, R., Rodríguez, P.L., Ponce, M.R., Micol, J.L. J. Exp. Bot. (2005) [Pubmed]
  10. A mechanism of nonphotochemical energy dissipation, independent from PsbS, revealed by a conformational change in the antenna protein CP26. Dall'Osto, L., Caffarri, S., Bassi, R. Plant Cell (2005) [Pubmed]
  11. Both abscisic acid (ABA)-dependent and ABA-independent pathways govern the induction of NCED3, AAO3 and ABA1 in response to salt stress. Barrero, J.M., Rodríguez, P.L., Quesada, V., Piqueras, P., Ponce, M.R., Micol, J.L. Plant Cell Environ. (2006) [Pubmed]
  12. Heat stress phenotypes of Arabidopsis mutants implicate multiple signaling pathways in the acquisition of thermotolerance. Larkindale, J., Hall, J.D., Knight, M.R., Vierling, E. Plant Physiol. (2005) [Pubmed]
  13. Altered xanthophyll compositions adversely affect chlorophyll accumulation and nonphotochemical quenching in Arabidopsis mutants. Pogson, B.J., Niyogi, K.K., Björkman, O., DellaPenna, D. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  14. Xanthophyll cycle enzymes are members of the lipocalin family, the first identified from plants. Bugos, R.C., Hieber, A.D., Yamamoto, H.Y. J. Biol. Chem. (1998) [Pubmed]
  15. The genes ABI1 and ABI2 are involved in abscisic acid- and drought-inducible expression of the Daucus carota L. Dc3 promoter in guard cells of transgenic Arabidopsis thaliana (L.) Heynh. Chak, R.K., Thomas, T.L., Quatrano, R.S., Rock, C.D. Planta (2000) [Pubmed]
  16. Yeast complementation reveals a role for an Arabidopsis thaliana late embryogenesis abundant (LEA)-like protein in oxidative stress tolerance. Mowla, S.B., Cuypers, A., Driscoll, S.P., Kiddle, G., Thomson, J., Foyer, C.H., Theodoulou, F.L. Plant J. (2006) [Pubmed]
  17. The Arabidopsis homeobox gene ATHB-7 is induced by water deficit and by abscisic acid. Söderman, E., Mattsson, J., Engström, P. Plant J. (1996) [Pubmed]
  18. Differential expression of two P5CS genes controlling proline accumulation during salt-stress requires ABA and is regulated by ABA1, ABI1 and AXR2 in Arabidopsis. Strizhov, N., Abrahám, E., Okrész, L., Blickling, S., Zilberstein, A., Schell, J., Koncz, C., Szabados, L. Plant J. (1997) [Pubmed]
  19. Two new alleles of the abscisic aldehyde oxidase 3 gene reveal its role in abscisic acid biosynthesis in seeds. González-Guzmán, M., Abia, D., Salinas, J., Serrano, R., Rodríguez, P.L. Plant Physiol. (2004) [Pubmed]
  20. Stress memory in plants: a negative regulation of stomatal response and transient induction of rd22 gene to light in abscisic acid-entrained Arabidopsis plants. Goh, C.H., Nam, H.G., Park, Y.S. Plant J. (2003) [Pubmed]
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