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Gene Review:

TFIIB - transcription initiation factor IIB-1

Arabidopsis thaliana

Synonyms: AtTFIIB1, T32G6.15, T32G6_15, TFIIB1, TRANSCRIPTION FACTOR TFIIB, ...

Baldwin, D.A. et al., Czarnecka-Verner, E. et al., Pan, S. et al.

Czarnecka-Verner, Pan, Salem, Gurley,

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High impact information on TFIIB

Protein binding experiments indicated that amino acid residues E-144 and E-146 of AtTBP2 are both essential for TFIIB binding in vitro [1].
Clones containing the complete coding regions for transcription factor IIB (TFIIB) were isolated from cDNA libraries of Arabidopsis and soybean [2].
Southern and Northern blots and primer extension for Arabidopsis TFIIB indicate a low copy number gene encodes a transcript of 1400 nt with a leader of 180 nt [2].
In vitro binding studies were consistent with this pattern of activity since the BD region alone interacted strongly with TFIIB, and the presence of RD had an inhibitory effect on TFIIB binding and transcriptional activation [3].

References

Role of the TATA binding protein-transcription factor IIB interaction in supporting basal and activated transcription in plant cells. Pan, S., Czarnecka-Verner, E., Gurley, W.B. Plant Cell (2000) [Pubmed]
Isolation and characterization of cDNAs encoding transcription factor IIB from Arabidopsis and soybean. Baldwin, D.A., Gurley, W.B. Plant J. (1996) [Pubmed]
Plant class B HSFs inhibit transcription and exhibit affinity for TFIIB and TBP. Czarnecka-Verner, E., Pan, S., Salem, T., Gurley, W.B. Plant Mol. Biol. (2004) [Pubmed]

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