Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

HB-1 - homeobox-leucine zipper protein HAT5

Arabidopsis thaliana

Synonyms: ARABIDOPSIS THALIANA HOMEOBOX 1, ATHB-1, ATHB1, F4P13.2, F4P13_2, ...

Aoyama, T. et al., Sessa, G. et al.

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High impact information on ATHB-1

Here we report an analysis of the DNA binding properties of the Athb-1 homeodomain-leucine zipper (HD-Zip-1) domain in vitro [1].
The Arabidopsis Athb-1 and -2 proteins are characterized by the presence of a homeodomain (HD) with a closely linked leucine zipper motif (Zip) [1].
The Arabidopsis thaliana Athb-1 is a homeobox gene of unknown function [2].
Athb-1 was found to transactivate a promoter linked to a specific DNA binding site by transient expression assays [2].
Both developmental phenotypes were induced by glucocorticoid in transgenic plants expressing a chimeric transcription factor comprising the Athb-1 DNA binding domain, the VP16 transactivating domain, and the glucocorticoid receptor domain [2].

Associations of ATHB-1 with chemical compounds

DNA binding analysis performed using random-sequence DNA templates showed that the HD-Zip-1 domain, but not the Athb-1 HD alone, binds to DNA [1].

References

The Athb-1 and -2 HD-Zip domains homodimerize forming complexes of different DNA binding specificities. Sessa, G., Morelli, G., Ruberti, I. EMBO J. (1993) [Pubmed]
Ectopic expression of the Arabidopsis transcriptional activator Athb-1 alters leaf cell fate in tobacco. Aoyama, T., Dong, C.H., Wu, Y., Carabelli, M., Sessa, G., Ruberti, I., Morelli, G., Chua, N.H. Plant Cell (1995) [Pubmed]

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