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Gene Review

REV  -  homeobox-leucine zipper protein REVOLUTA

Arabidopsis thaliana

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Disease relevance of REV

  • Here we report the structural and functional characterisation of a dehydration responsive nuclear-targeted HDZip transcriptional regulator, CpHB-7 [1].
  • Chemo-attraction was observed in Nostoc strains 8964:3 and PCC 73102 towards exudate or crushed extract of the natural hosts Gunnera manicata, Cycas revoluta and Blasia pusilla, and the nonhost plants Trifolium repens, Arabidopsis thaliana and Oryza sativa [2].

High impact information on REV


Chemical compound and disease context of REV


Biological context of REV


Associations of REV with chemical compounds


Other interactions of REV

  • PHB, PHV and REV transcripts contain a complementary site for miRNA165 and miRNA166, which can direct their cleavage in vitro [17].
  • Loss of KANADI activity results in similar alterations in vascular patterning as compared to REVOLUTA gain-of-function alleles [18].
  • Simultaneous loss-of-function of PHABULOSA, PHAVOLUTA, and REVOLUTA abaxializes cotyledons, abolishes the formation of the primary apical meristem, and in severe cases, eliminates bilateral symmetry; these phenotypes implicate these three genes in radial patterning of both embryonic and postembryonic growth [18].
  • RESULTS: We show that gain-of-function alleles of REVOLUTA, another member of the class III HD-ZIP gene family, are characterized by adaxialized lateral organs and alterations in the radial patterning of vascular bundles in the stem [18].
  • ZeHB-10, -11 and -12 encode for HD-Zip proteins of the class III to which Arabidopsis Athb-8, -9, -14, -15 and IFL1 belong [19].

Analytical, diagnostic and therapeutic context of REV


  1. A homeodomain leucine zipper gene from Craterostigma plantagineum regulates abscisic acid responsive gene expression and physiological responses. Deng, X., Phillips, J., Bräutigam, A., Engström, P., Johannesson, H., Ouwerkerk, P.B., Ruberti, I., Salinas, J., Vera, P., Iannacone, R., Meijer, A.H., Bartels, D. Plant Mol. Biol. (2006) [Pubmed]
  2. Cyanobacterial chemotaxis to extracts of host and nonhost plants. Nilsson, M., Rasmussen, U., Bergman, B. FEMS Microbiol. Ecol. (2006) [Pubmed]
  3. The Athb-1 and -2 HD-Zip domains homodimerize forming complexes of different DNA binding specificities. Sessa, G., Morelli, G., Ruberti, I. EMBO J. (1993) [Pubmed]
  4. A novel class of plant proteins containing a homeodomain with a closely linked leucine zipper motif. Ruberti, I., Sessa, G., Lucchetti, S., Morelli, G. EMBO J. (1991) [Pubmed]
  5. The Proteolytic Function of the Arabidopsis 26S Proteasome Is Required for Specifying Leaf Adaxial Identity. Huang, W., Pi, L., Liang, W., Xu, B., Wang, H., Cai, R., Huang, H. Plant Cell (2006) [Pubmed]
  6. A new homeodomain-leucine zipper gene from Arabidopsis thaliana induced by water stress and abscisic acid treatment. Lee, Y.H., Chun, J.Y. Plant Mol. Biol. (1998) [Pubmed]
  7. Class III homeodomain-leucine zipper gene family members have overlapping, antagonistic, and distinct roles in Arabidopsis development. Prigge, M.J., Otsuga, D., Alonso, J.M., Ecker, J.R., Drews, G.N., Clark, S.E. Plant Cell (2005) [Pubmed]
  8. Regulation of Arabidopsis shoot apical meristem and lateral organ formation by microRNA miR166g and its AtHD-ZIP target genes. Williams, L., Grigg, S.P., Xie, M., Christensen, S., Fletcher, J.C. Development (2005) [Pubmed]
  9. IFL1, a gene regulating interfascicular fiber differentiation in Arabidopsis, encodes a homeodomain-leucine zipper protein. Zhong, R., Ye, Z.H. Plant Cell (1999) [Pubmed]
  10. CORONA, a member of the class III homeodomain leucine zipper gene family in Arabidopsis, regulates stem cell specification and organogenesis. Green, K.A., Prigge, M.J., Katzman, R.B., Clark, S.E. Plant Cell (2005) [Pubmed]
  11. AINTEGUMENTA contributes to organ polarity and regulates growth of lateral organs in combination with YABBY genes. Nole-Wilson, S., Krizek, B.A. Plant Physiol. (2006) [Pubmed]
  12. REVOLUTA regulates meristem initiation at lateral positions. Otsuga, D., DeGuzman, B., Prigge, M.J., Drews, G.N., Clark, S.E. Plant J. (2001) [Pubmed]
  13. Light and shade in the photocontrol of Arabidopsis growth. Morelli, G., Ruberti, I. Trends Plant Sci. (2002) [Pubmed]
  14. Homeodomain leucine zipper class I genes in Arabidopsis. Expression patterns and phylogenetic relationships. Henriksson, E., Olsson, A.S., Johannesson, H., Johansson, H., Hanson, J., Engström, P., Söderman, E. Plant Physiol. (2005) [Pubmed]
  15. Induction of a homeodomain-leucine zipper gene by auxin is inhibited by cytokinin in Arabidopsis roots. Son, O., Cho, H.Y., Kim, M.R., Lee, H., Lee, M.S., Song, E., Park, J.H., Nam, K.H., Chun, J.Y., Kim, H.J., Hong, S.K., Chung, Y.Y., Hur, C.G., Cho, H.T., Cheon, C.I. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  16. Amphivasal vascular bundle 1, a gain-of-function mutation of the IFL1/REV gene, is associated with alterations in the polarity of leaves, stems and carpels. Zhong, R., Ye, Z.H. Plant Cell Physiol. (2004) [Pubmed]
  17. microRNA-mediated repression of rolled leaf1 specifies maize leaf polarity. Juarez, M.T., Kui, J.S., Thomas, J., Heller, B.A., Timmermans, M.C. Nature (2004) [Pubmed]
  18. Radial patterning of Arabidopsis shoots by class III HD-ZIP and KANADI genes. Emery, J.F., Floyd, S.K., Alvarez, J., Eshed, Y., Hawker, N.P., Izhaki, A., Baum, S.F., Bowman, J.L. Curr. Biol. (2003) [Pubmed]
  19. Promotion of transcript accumulation of novel Zinnia immature xylem-specific HD-Zip III homeobox genes by brassinosteroids. Ohashi-Ito, K., Demura, T., Fukuda, H. Plant Cell Physiol. (2002) [Pubmed]
  20. Developmental and seasonal expression of PtaHB1, a Populus gene encoding a class III HD-Zip protein, is closely associated with secondary growth and inversely correlated with the level of microRNA (miR166). Ko, J.H., Prassinos, C., Han, K.H. New Phytol. (2006) [Pubmed]
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