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Gene Review

ARC5  -  dynamin-like protein ARC5

Arabidopsis thaliana

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High impact information on ARC5

  • Our results indicate that plastid division involves the stepwise localization of FtsZ, PDV1, and ARC5 at the division site and that PDV1 and PDV2 together mediate the recruitment of ARC5 to the midplastid constriction at a late stage of division [1].
  • During plastid division, the dynamin-related protein ACCUMULATION AND REPLICATION OF CHLOROPLASTS5 (ARC5) is recruited from the cytosol to the surface of the outer chloroplast envelope membrane [1].
  • ARC5, a cytosolic dynamin-like protein from plants, is part of the chloroplast division machinery [2].
  • The ARC5 gene product shares similarity with the dynamin family of GTPases, which mediate endocytosis, mitochondrial division, and other organellar fission and fusion events in eukaryotes [2].
  • ARC1 down-regulates proplastid division but is on a separate pathway from ARC3, ARC5, ARC6 and ARC11 [3].

Biological context of ARC5

  • Arc5 production could be enhanced to more than 24% of the total seed protein content, suggesting that antisense technology could be of great utility to favor high expression of transgenes [4].

Anatomical context of ARC5

  • As the arc5 chloroplasts expand and elongate without dividing, the internal thylakoid membrane structure becomes flexed into an undulating ribbon [5].


  1. PDV1 and PDV2 Mediate Recruitment of the Dynamin-Related Protein ARC5 to the Plastid Division Site. Miyagishima, S.Y., Froehlich, J.E., Osteryoung, K.W. Plant Cell (2006) [Pubmed]
  2. ARC5, a cytosolic dynamin-like protein from plants, is part of the chloroplast division machinery. Gao, H., Kadirjan-Kalbach, D., Froehlich, J.E., Osteryoung, K.W. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  3. The distinctive roles of five different ARC genes in the chloroplast division process in Arabidopsis. Marrison, J.L., Rutherford, S.M., Robertson, E.J., Lister, C., Dean, C., Leech, R.M. Plant J. (1999) [Pubmed]
  4. Co-introduction of an antisense gene for an endogenous seed storage protein can increase expression of a transgene in Arabidopsis thaliana seeds. Goossens, A., Van Montagu, M., Angenon, G. FEBS Lett. (1999) [Pubmed]
  5. Characterization of chloroplast division using the Arabidopsis mutant arc5. Robertson, E.J., Rutherford, S.M., Leech, R.M. Plant Physiol. (1996) [Pubmed]
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