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DL1  -  dynamin-related protein 1A

Arabidopsis thaliana

Synonyms: ADL1, ADL1A, AG68, DRP1A, DYNAMIN-RELATED PROTEIN 1A, ...
 
 
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High impact information on ADL1

 

Biological context of ADL1

 

Anatomical context of ADL1

 

Associations of ADL1 with chemical compounds

  • Ca2+ increases the amount of ADL1 present in the membrane fraction, whereas cyclosporin A inhibits the membrane association [5].
  • Furthermore, Ca2+ and GTP change the migration pattern of ADL1 in nondenaturing polyacrylamide gels, indicating that these chemicals influence either the complex formation and/or the conformation of the ADL1 complex [5].
  • Despite the loss of ADL1Ap, the mutants did not display any defects in cytokinesis, and growth of the mutant seedlings could be rescued in tissue culture by the addition of sucrose [8].
 

Other interactions of ADL1

 

Analytical, diagnostic and therapeutic context of ADL1

  • Subcellular fractionation experiments, together with gel-filtration and nondenaturing-gel electrophoresis revealed that most of ADL1 is present as a high-molecular-mass complex of 400 to 600 kD in the membrane or pellet fraction, whereas ADL1 is present in the soluble fraction as a monomer [5].
  • Immunoblotting revealed that ADL1Ap expression was not detectable in the mutants [8].

References

  1. A dynamin-like protein in Arabidopsis thaliana is involved in biogenesis of thylakoid membranes. Park, J.M., Cho, J.H., Kang, S.G., Jang, H.J., Pih, K.T., Piao, H.L., Cho, M.J., Hwang, I. EMBO J. (1998) [Pubmed]
  2. Members of the Arabidopsis dynamin-like gene family, ADL1, are essential for plant cytokinesis and polarized cell growth. Kang, B.H., Busse, J.S., Bednarek, S.Y. Plant Cell (2003) [Pubmed]
  3. The dynamin-like protein ADL1C is essential for plasma membrane maintenance during pollen maturation. Kang, B.H., Rancour, D.M., Bednarek, S.Y. Plant J. (2003) [Pubmed]
  4. The Arabidopsis KNOLLE and KEULE genes interact to promote vesicle fusion during cytokinesis. Waizenegger, I., Lukowitz, W., Assaad, F., Schwarz, H., Jürgens, G., Mayer, U. Curr. Biol. (2000) [Pubmed]
  5. A dynamin-like protein, ADL1, is present in membranes as a high-molecular-mass complex in Arabidopsis thaliana. Park, J.M., Kang, S.G., Pih, K.T., Jang, H.J., Piao, H.L., Yoon, H.W., Cho, M.J., Hwang, I. Plant Physiol. (1997) [Pubmed]
  6. Phragmoplastin dynamics: multiple forms, microtubule association and their roles in cell plate formation in plants. Hong, Z., Geisler-Lee, C.J., Zhang, Z., Verma, D.P. Plant Mol. Biol. (2003) [Pubmed]
  7. A new dynamin-like protein, ADL6, is involved in trafficking from the trans-Golgi network to the central vacuole in Arabidopsis. Jin, J.B., Kim, Y.A., Kim, S.J., Lee, S.H., Kim, D.H., Cheong, G.W., Hwang, I. Plant Cell (2001) [Pubmed]
  8. The arabidopsis cell plate-associated dynamin-like protein, ADL1Ap, is required for multiple stages of plant growth and development. Kang, B.H., Busse, J.S., Dickey, C., Rancour, D.M., Bednarek, S.Y. Plant Physiol. (2001) [Pubmed]
  9. DRP1A is responsible for vascular continuity synergistically working with VAN3 in Arabidopsis. Sawa, S., Koizumi, K., Naramoto, S., Demura, T., Ueda, T., Nakano, A., Fukuda, H. Plant Physiol. (2005) [Pubmed]
  10. ARC5, a cytosolic dynamin-like protein from plants, is part of the chloroplast division machinery. Gao, H., Kadirjan-Kalbach, D., Froehlich, J.E., Osteryoung, K.W. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
 
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