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Gene Review

PCL1  -  transcription factor LUX

Arabidopsis thaliana

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Disease relevance of PCL1


High impact information on PCL1

  • Mathematical modeling indicated that the modest change in peak LUX RNA abundance was sufficient to cause the period change due to FLC, providing a molecular target for the crosstalk between flowering time pathways and circadian regulation [2].
  • The data are also consistent with LUX being necessary for activation of CCA1 and LHY expression [3].
  • LUX ARRHYTHMO encodes a Myb domain protein essential for circadian rhythms [3].
  • Therefore, the PCL1 gene is the clock oscillator gene essential to the generation of clock oscillation in the higher plant [1].
  • Here we succeeded to clone the PCL1 gene and show that the PCL1 gene encodes a novel DNA binding protein belonging to the GARP protein family and is essential for a functional clock oscillator in A. thaliana [1].


  1. PHYTOCLOCK 1 encoding a novel GARP protein essential for the Arabidopsis circadian clock. Onai, K., Ishiura, M. Genes Cells (2005) [Pubmed]
  2. FLOWERING LOCUS C mediates natural variation in the high-temperature response of the Arabidopsis circadian clock. Edwards, K.D., Anderson, P.E., Hall, A., Salathia, N.S., Locke, J.C., Lynn, J.R., Straume, M., Smith, J.Q., Millar, A.J. Plant Cell (2006) [Pubmed]
  3. LUX ARRHYTHMO encodes a Myb domain protein essential for circadian rhythms. Hazen, S.P., Schultz, T.F., Pruneda-Paz, J.L., Borevitz, J.O., Ecker, J.R., Kay, S.A. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
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