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Gene Review

LHY  -  protein LHY

Arabidopsis thaliana

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High impact information on LHY


Biological context of LHY

  • Unexpectedly, translational induction coincided with acute downregulation of LHY transcript levels [4].
  • In addition, we demonstrate that two other circadian rhythm mutants, LHY-ox and elf3, have low-viability phenotypes [5].
  • The daily onset of LHY gene expression was advanced by approximately 4 h in det1-1 mutant plants, suggesting that the wild-type DET1 protein might function to repress its transcription during the subjective night. lhy-1 det1-1 double mutants exhibited arrhythmic expression of the CAB gene in constant light, similar to the lhy-1 mutant parent [6].
  • Furthermore, binding assays with Arabidopsis (Arabidopsis thaliana) late elongated hypocotyl, a transcription factor of Arabidopsis involved in circadian regulation, clearly revealed the presence of circadian-determining regulatory elements in the promoter region of PcISPS [7].

Regulatory relationships of LHY


Other interactions of LHY

  • ELF3 is also necessary for light-induced CCA1/LHY expression, but it is neither light-induced nor clock-regulated during de-etiolation [8].
  • Transfer to constant red light (Rc) rapidly induces a biphasic pattern of CCA1 and LHY expression, and a reciprocal TOC1 expression pattern over the first 24 h, consistent with initial induction of this synchronous oscillation by the light signal [8].
  • As previously reported, the gi-2 mutation affects the period length and amplitude of CCA1 and LHY expression, and GI may act through a feedback loop to maintain a proper circadian function [9].
  • Here we show that plants overexpressing CKB3, a regulatory subunit of CK2, display increased CK2 activity and shorter periods of rhythmic expression of CCA1 and LHY [10].
  • Over-expression of both CCA1 and LHY genes causes the elimination of GBSSI mRNA oscillation [11].


  1. Constitutive expression of the CIRCADIAN CLOCK ASSOCIATED 1 (CCA1) gene disrupts circadian rhythms and suppresses its own expression. Wang, Z.Y., Tobin, E.M. Cell (1998) [Pubmed]
  2. The late elongated hypocotyl mutation of Arabidopsis disrupts circadian rhythms and the photoperiodic control of flowering. Schaffer, R., Ramsay, N., Samach, A., Corden, S., Putterill, J., Carré, I.A., Coupland, G. Cell (1998) [Pubmed]
  3. Reciprocal regulation between TOC1 and LHY/CCA1 within the Arabidopsis circadian clock. Alabadí, D., Oyama, T., Yanovsky, M.J., Harmon, F.G., Más, P., Kay, S.A. Science (2001) [Pubmed]
  4. Light-regulated translation mediates gated induction of the Arabidopsis clock protein LHY. Kim, J.Y., Song, H.R., Taylor, B.L., Carré, I.A. EMBO J. (2003) [Pubmed]
  5. Circadian rhythms confer a higher level of fitness to Arabidopsis plants. Green, R.M., Tingay, S., Wang, Z.Y., Tobin, E.M. Plant Physiol. (2002) [Pubmed]
  6. DET1 regulates the proteasomal degradation of LHY, a component of the Arabidopsis circadian clock. Song, H.R., Carré, I.A. Plant Mol. Biol. (2005) [Pubmed]
  7. Circadian rhythms of isoprene biosynthesis in grey poplar leaves. Loivam??ki, M., Louis, S., Cinege, G., Zimmer, I., Fischbach, R.J., Schnitzler, J.P. Plant Physiol. (2007) [Pubmed]
  8. ELF4 is a phytochrome-regulated component of a negative-feedback loop involving the central oscillator components CCA1 and LHY. Kikis, E.A., Khanna, R., Quail, P.H. Plant J. (2005) [Pubmed]
  9. RFI2, a RING-domain zinc finger protein, negatively regulates CONSTANS expression and photoperiodic flowering. Chen, M., Ni, M. Plant J. (2006) [Pubmed]
  10. The protein kinase CK2 is involved in regulation of circadian rhythms in Arabidopsis. Sugano, S., Andronis, C., Ong, M.S., Green, R.M., Tobin, E.M. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  11. Oscillation of mRNA level and activity of granule-bound starch synthase I in Arabidopsis leaves during the day/night cycle. Tenorio, G., Orea, A., Romero, J.M., Mérida, A. Plant Mol. Biol. (2003) [Pubmed]
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