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Gene Review:

MSH4 - DNA mismatch repair protein MSH4

Arabidopsis thaliana

Synonyms: ARABIDOPSIS MUTS HOMOLOG 4, ARABIDOPSIS MUTS HOMOLOG 4, ATMSH4, DL4725W, FCAALL.423, ...

Franklin, F.C. et al., Jackson, N. et al.

Franklin, Higgins, Sanchez-Moran, Armstrong, Osman, Jackson, Jones,

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High impact information on MSH4

Localization of the MutS homologue AtMSH4 occurs, suggesting that double Holliday junctions (dHjs) are formed, but the MutL homologue AtMLH1, which forms a heterocomplex with AtMLH3, fails to localize normally [1].
This is consistent with a two-pathway model for meiotic crossing-over whereby most crossovers occur via an AtMSH4-dependent pathway that is subject to interference, with the remaining crossovers arising via an interference-independent pathway [2].

Biological context of MSH4

Immunocytochemistry reveals that the Arabidopsis mismatch repair proteins AtMSH4, AtMLH3 and AtMLH1 are expressed during prophase I of meiosis [2].

References

Reduced meiotic crossovers and delayed prophase I progression in AtMLH3-deficient Arabidopsis. Jackson, N., Sanchez-Moran, E., Buckling, E., Armstrong, S.J., Jones, G.H., Franklin, F.C. EMBO J. (2006) [Pubmed]
Control of meiotic recombination in Arabidopsis: role of the MutL and MutS homologues. Franklin, F.C., Higgins, J.D., Sanchez-Moran, E., Armstrong, S.J., Osman, K.E., Jackson, N., Jones, G.H. Biochem. Soc. Trans. (2006) [Pubmed]

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