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Gene Review

him-14  -  Protein HIM-14

Caenorhabditis elegans

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High impact information on him-14

  • Overexpression of the klp-3 gene partially rescues the lethal phenotype of the maternal lethal him-14 ts(it44) mutants at non-permissive temperatures, and reduces the incidence of males caused by non-disjunction of the X-chromosome [1].
  • Loss of him-14 function severely reduces crossing over, resulting in lack of chiasmata between homologs and consequent missegregation [2].
  • Formation of crossovers between homologous chromosomes during Caenorhabditis elegans meiosis requires the him-14 gene [2].
  • In rec-1; him-6 and rec-1; him-14 homozygotes the frequency of crossing over was characteristic of the Him mutant phenotype, whereas the distribution of the reduced number of exchanges was characteristic of the Rec-1 pattern [3].


  1. Molecular cloning and expression of the Caenorhabditis elegans klp-3, an ortholog of C terminus motor kinesins Kar3 and ncd. Khan, M.L., Gogonea, C.B., Siddiqui, Z.K., Ali, M.Y., Kikuno, R., Nishikawa, K., Siddiqui, S.S. J. Mol. Biol. (1997) [Pubmed]
  2. Crossing over during Caenorhabditis elegans meiosis requires a conserved MutS-based pathway that is partially dispensable in budding yeast. Zalevsky, J., MacQueen, A.J., Duffy, J.B., Kemphues, K.J., Villeneuve, A.M. Genetics (1999) [Pubmed]
  3. Mutant rec-1 eliminates the meiotic pattern of crossing over in Caenorhabditis elegans. Zetka, M.C., Rose, A.M. Genetics (1995) [Pubmed]
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