Disease relevance of Msh4

• Disruption of the Msh4 gene in mice results in male and female sterility due to meiotic failure [1].

High impact information on Msh4

• Although meiosis is initiated in Msh4 mutant male and female mice, as indicated by the chromosomal localization of RAD51 and COR1 during leptonema/zygonema, the chromosomes fail to undergo normal pairing [1].
• Most Msh4 variant mRNAs are mainly expressed in testis, but a small amount of each variant except for epsilon is also expressed in brain, heart, thymus, ovary and embryonic head [2].
• This study suggests that the dynamic interchromosomal (intergenic) trans-splicing generates functional diversity of the mouse Msh4 gene [2].
• By degenerate PCR and screening of mouse testis cDNA library, we have identified seven cDNAs from the meiotic recombination gene Msh4 [2].
• Family of SRY/Sox proteins is involved in the regulation of the mouse Msh4 (MutS Homolog 4) gene expression [3].

Biological context of Msh4

• We demonstrated a promoter activity of the mMsh4 5'-flanking region by cell transfection experiments with a luciferase reporter gene [3].

Anatomical context of Msh4

• We examined the expression of mMsh4 in testes of increasing developmental age and in elutriated germ cells [3].

References