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Gene Review

Msh4  -  mutS homolog 4 (E. coli)

Mus musculus

Synonyms: 4930485C04Rik, AV144863, MutS protein homolog 4, mMsh4
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Disease relevance of Msh4

  • Disruption of the Msh4 gene in mice results in male and female sterility due to meiotic failure [1].

High impact information on Msh4

  • Although meiosis is initiated in Msh4 mutant male and female mice, as indicated by the chromosomal localization of RAD51 and COR1 during leptonema/zygonema, the chromosomes fail to undergo normal pairing [1].
  • Most Msh4 variant mRNAs are mainly expressed in testis, but a small amount of each variant except for epsilon is also expressed in brain, heart, thymus, ovary and embryonic head [2].
  • This study suggests that the dynamic interchromosomal (intergenic) trans-splicing generates functional diversity of the mouse Msh4 gene [2].
  • By degenerate PCR and screening of mouse testis cDNA library, we have identified seven cDNAs from the meiotic recombination gene Msh4 [2].
  • Family of SRY/Sox proteins is involved in the regulation of the mouse Msh4 (MutS Homolog 4) gene expression [3].

Biological context of Msh4


Anatomical context of Msh4


  1. MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice. Kneitz, B., Cohen, P.E., Avdievich, E., Zhu, L., Kane, M.F., Hou, H., Kolodner, R.D., Kucherlapati, R., Pollard, J.W., Edelmann, W. Genes Dev. (2000) [Pubmed]
  2. Genomic organization of the mouse Msh4 gene producing bicistronic, chimeric and antisense mRNA. Hirano, M., Noda, T. Gene (2004) [Pubmed]
  3. Family of SRY/Sox proteins is involved in the regulation of the mouse Msh4 (MutS Homolog 4) gene expression. Santucci-Darmanin, S., Vidal, F., Scimeca, J.C., Turc-Carel, C., Paquis-Flucklinger, V. Mol. Reprod. Dev. (2001) [Pubmed]
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