Disease relevance of NPR4

• Plants with T-DNA insertions in NPR4 are more susceptible to the virulent bacterial pathogen Pseudomonas syringe pv. tomato DC3000 [1].

High impact information on NPR4

• This enhanced disease resistance is partially dependent on NPR1, can be in part complemented by either wild-type NPR3 or NPR4, and is not associated with an elevated level of salicylic acid [2].
• In leaves of wild-type plants, NPR4 mRNA levels increase following pathogen challenge or SA treatment, and decrease rapidly following methyl jasmonic acid (MeJA) treatment [1].
• An Arabidopsis NPR1-like gene, NPR4, is required for disease resistance [1].
• This phenotype is complemented by expression of the wild type NPR4 coding region [1].
• Reverse genetics was used to analyze the role of one NPR1-like gene, which we called NPR4 [1].

Analytical, diagnostic and therapeutic context of NPR4

• The NPR4 protein shares 36% identity with NPR1 and interacts with the same spectrum of TGA transcription factors in yeast two-hybrid assays [1].

References