The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

AC1NQZAV     methyl2-[(1R,2R)-3-oxo-2- [(Z)-pent-2...

Synonyms: SureCN36186, CHEBI:15929, CMC_7389, Ambap1211-29-6, LMFA02020010, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Methyljasmonate


High impact information on Methyljasmonate

  • Treatment of plants with methyl jasmonate (MeJA) increased the total binding of [(3)H]-l-volicitin to the enriched plasma membrane more than threefold, suggesting that MeJA activates transcription of the gene encoding the binding protein [4].
  • In contrast to previous reports, no major increase in jasmonic acid (JA) and methyl jasmonate (MJ) was detected after the activation of SIPK/WIPK in NtMEK2DD transgenic plants [5].
  • The antisense plants do produce both PG activity and H2O2 when supplied with systemin, OGA, chitosan, or MJ [6].
  • In leaves of wild-type plants, NPR4 mRNA levels increase following pathogen challenge or SA treatment, and decrease rapidly following methyl jasmonic acid (MeJA) treatment [7].
  • Expression of the jasmonic acid-dependent pathway marker gene PDF1.2 is compromised in npr4-1 leaves following application of MeJA or a combination of SA and MeJA [7].

Biological context of Methyljasmonate

  • The mutation, termed ore4-1, delays a broad spectrum of age-dependent leaf senescence, but has little effect on leaf senescence artificially induced by darkness, abscisic acid (ABA), methyl jasmonate (MeJA), or ethylene [8].
  • Orca3 mRNA accumulation was rapidly induced by the plant stress hormone methyljasmonate with biphasic kinetics [9].
  • Furthermore, the 'conditioning' of developmental upregulation in flowers, the response to MeJa in flowers and leaves, and the parenchyma-specific expression are all mediated by the cis-elements within the proximal 192 bp of the promoter [10].
  • A competitive inhibitor of ethylene (2,5-norbornadiene; NBD) down-regulated the effect of MeJA on sporamin gene expression [11].
  • These data demonstrate that the promoter regions used in these experiments contain cis-acting regulatory elements required for proper regulation of tomlox expression during development and for MeJa-responsiveness [12].

Anatomical context of Methyljasmonate

  • MJ also induced the differentiation of other human leukemia cell lines [2].
  • MJ induced both monocytic and granulocytic differentiation of HL-60 cells [2].
  • Aggregated suspension cultures, protoplasts, and single cells did not show any change in total protein content following elicitation with MJ at 200 microM on day 7 [13].
  • A change in total enzyme activity in cultured cells was observed only at the highest concentration of MeJ and not at any level of ASA tested [14].
  • It appears that while prolonged exposures to relatively low concentrations of jasmonates induce growth arrest and re-differentiation in myeloid leukemia cells, higher concentrations of MJ induce direct perturbation of cancer cell mitochondria, leading to the release of cytochrome c and eventual cell death [15].

Associations of Methyljasmonate with other chemical compounds

  • Analysis of UGT expression in Arabidopsis defense-signaling mutants further revealed that their induction is methyljasmonate independent, but partially salicylic acid dependent [1].
  • Glucosinolate content was analyzed in Arabidopsis wild-type plants in response to single or combinatorial treatments with methyljasmonate (MeJA), 2,6-dichloro-isonicotinic acid, ethylene, and 2,4-dichloro-phenoxyacetic acid, or by wounding [16].
  • Moreover, eds4-1 and eds8-1 showed reduced expression of the plant defensin gene PDF1.2 after MeJA and ACC treatment, which was associated with reduced sensitivity to either ET (eds4-1) or MeJA (eds8-1) [17].
  • In addition, an appreciable increase in phenylalanine ammonia-lyase activity occurred only in methyl-jasmonate-treated cell cultures of H. androsaemum [18].
  • In contrast, when leaf senescence was induced by ethylene, ABA or methyljasmonate, the transcript level detected by the clones was differentially regulated depending on the senescence-inducing hormones [19].

Gene context of Methyljasmonate

  • Transcripts of OPR3 rapidly accumulated in leaves after wounding and MeJA treatment, but they were detected in various tissues of unwounded plants at relatively low levels [20].
  • MJ activated mitogen-activated protein kinase (MAPK) in the cells before causing myelomonocytic differentiation [2].
  • MAPK activation was necessary for MJ-induced differentiation, since PD98059, an inhibitor of MAPK kinase, suppressed the differentiation induced by MJ [2].
  • Shoot-applied MeJA strongly suppressed nodulation in the wild type and even hypernodulation in the har1 mutant, whereas MeSA exhibited no effect [21].
  • Trans-2-hexenal induction thus closely mimics the group of genes induced by methyl jasmonate (MeJA), also a LOX-derived volatile [22].

Analytical, diagnostic and therapeutic context of Methyljasmonate

  • The expression of both genes was up-regulated by addition of MJ to the cell cultures although the mRNA level of CaUGT1 was much lower than that of CaUGT2 [23].
  • A general responsiveness in methyl-jasmonate-treated leaves was demonstrated by in situ hybridization [24].
  • After screening various signal transducers, it was clear that methyl jasmonate (MeJA) markedly promoted saikosaponin production [25].
  • The high-performance liquid chromatography (HPLC) profile of LCOs isolated following treatment with jasmonates or genistein showed that both JA and MeJA effectively induced nod genes and caused production of LCOs from bacterial cultures [26].


  1. Pathogen-responsive expression of glycosyltransferase genes UGT73B3 and UGT73B5 is necessary for resistance to Pseudomonas syringae pv tomato in Arabidopsis. Langlois-Meurinne, M., Gachon, C.M., Saindrenan, P. Plant Physiol. (2005) [Pubmed]
  2. Induction of differentiation of human myeloid leukemia cells by jasmonates, plant hormones. Ishii, Y., Kiyota, H., Sakai, S., Honma, Y. Leukemia (2004) [Pubmed]
  3. Plant stress hormones suppress the proliferation and induce apoptosis in human cancer cells. Fingrut, O., Flescher, E. Leukemia (2002) [Pubmed]
  4. A plasma membrane protein from Zea mays binds with the herbivore elicitor volicitin. Truitt, C.L., Wei, H.X., Paré, P.W. Plant Cell (2004) [Pubmed]
  5. Activation of a stress-responsive mitogen-activated protein kinase cascade induces the biosynthesis of ethylene in plants. Kim, C.Y., Liu, Y., Thorne, E.T., Yang, H., Fukushige, H., Gassmann, W., Hildebrand, D., Sharp, R.E., Zhang, S. Plant Cell (2003) [Pubmed]
  6. Hydrogen peroxide is generated systemically in plant leaves by wounding and systemin via the octadecanoid pathway. Orozco-Cardenas, M., Ryan, C.A. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  7. An Arabidopsis NPR1-like gene, NPR4, is required for disease resistance. Liu, G., Holub, E.B., Alonso, J.M., Ecker, J.R., Fobert, P.R. Plant J. (2005) [Pubmed]
  8. Extended leaf longevity in the ore4-1 mutant of Arabidopsis with a reduced expression of a plastid ribosomal protein gene. Woo, H.R., Goh, C.H., Park, J.H., Teyssendier de la Serve, B., Kim, J.H., Park, Y.I., Nam, H.G. Plant J. (2002) [Pubmed]
  9. The jasmonate-inducible AP2/ERF-domain transcription factor ORCA3 activates gene expression via interaction with a jasmonate-responsive promoter element. van der Fits, L., Memelink, J. Plant J. (2001) [Pubmed]
  10. Expression of an amino acid biosynthesis gene in tomato flowers: developmental upregulation and MeJa response are parenchyma-specific and mutually compatible. Samach, A., Broday, L., Hareven, D., Lifschitz, E. Plant J. (1995) [Pubmed]
  11. Wound-response regulation of the sweet potato sporamin gene promoter region. Wang, S.J., Lan, Y.C., Chen, S.F., Chen, Y.M., Yeh, K.W. Plant Mol. Biol. (2002) [Pubmed]
  12. Developmental regulation of two tomato lipoxygenase promoters in transgenic tobacco and tomato. Beaudoin, N., Rothstein, S.J. Plant Mol. Biol. (1997) [Pubmed]
  13. Flow cytometric analysis of protein content in Taxus protoplasts and single cells as compared to aggregated suspension cultures. Naill, M.C., Roberts, S.C. Plant Cell Rep. (2005) [Pubmed]
  14. Elicitation of dihydrobenzophenanthridine oxidase in Sanguinaria canadensis cell cultures. Ignatov, A., Clark, W.G., Cline, S.D., Psenak, M., Krueger, J., Coscia, C.J. Phytochemistry (1996) [Pubmed]
  15. Jasmonates--a new family of anti-cancer agents. Flescher, E. Anticancer Drugs (2005) [Pubmed]
  16. Modulation of CYP79 genes and glucosinolate profiles in Arabidopsis by defense signaling pathways. Mikkelsen, M.D., Petersen, B.L., Glawischnig, E., Jensen, A.B., Andreasson, E., Halkier, B.A. Plant Physiol. (2003) [Pubmed]
  17. Characterization of Arabidopsis enhanced disease susceptibility mutants that are affected in systemically induced resistance. Ton, J., De Vos, M., Robben, C., Buchala, A., Métraux, J.P., Van Loon, L.C., Pieterse, C.M. Plant J. (2002) [Pubmed]
  18. Cinnamic acid is a precursor of benzoic acids in cell cultures of Hypericum androsaemum L. but not in cell cultures of Centaurium erythraea RAFN. Abd El-Mawla, A.M., Schmidt, W., Beerhues, L. Planta (2001) [Pubmed]
  19. Differential expression of senescence-associated mRNAs during leaf senescence induced by different senescence-inducing factors in Arabidopsis. Park, J.H., Oh, S.A., Kim, Y.H., Woo, H.R., Nam, H.G. Plant Mol. Biol. (1998) [Pubmed]
  20. An Arabidopsis gene induced by wounding functionally homologous to flavoprotein oxidoreductases. Costa, C.L., Arruda, P., Benedetti, C.E. Plant Mol. Biol. (2000) [Pubmed]
  21. Shoot-applied MeJA suppresses root nodulation in Lotus japonicus. Nakagawa, T., Kawaguchi, M. Plant Cell Physiol. (2006) [Pubmed]
  22. C6-volatiles derived from the lipoxygenase pathway induce a subset of defense-related genes. Bate, N.J., Rothstein, S.J. Plant J. (1998) [Pubmed]
  23. Molecular cloning and characterization of a glucosyltransferase catalyzing glucosylation of curcumin in cultured Catharanthus roseus cells. Kaminaga, Y., Sahin, F.P., Mizukami, H. FEBS Lett. (2004) [Pubmed]
  24. Regulation of the wound-induced myrosinase-associated protein transcript in Brassica napus plants. Taipalensuu, J., Andreasson, E., Eriksson, S., Rask, L. Eur. J. Biochem. (1997) [Pubmed]
  25. Efficient production of saikosaponins in Bupleurum falcatum root fragments combined with signal transducers. Aoyagi, H., Kobayashi, Y., Yamada, K., Yokoyama, M., Kusakari, K., Tanaka, H. Appl. Microbiol. Biotechnol. (2001) [Pubmed]
  26. Jasmonates induce Nod factor production by Bradyrhizobium japonicum. Mabood, F., Souleimanov, A., Khan, W., Smith, D.L. Plant Physiol. Biochem. (2006) [Pubmed]
WikiGenes - Universities