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Gene Review:

CAPS - calcyphosine

Homo sapiens

Synonyms: CAPS1, Calcyphosin, Calcyphosine, MGC126562

Clément, S. et al., El Housni, H. et al., Zheng, S.L. et al., Armagan, E. et al., De Bruyne, M.A. et al., et al.

Suzuki, Yuasa, De Bruyne, Rosiers, Nakatomi, Yazawa, De Moor, De Bruyne,

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Disease relevance of CAPS

AIM: (i) To compare the root-end sealing ability of IRM Caps (IRM), Fuji IX Capsules (Fuji IX) and Pro Root MTA Tooth-Coloured Formula (MTA) in teeth obtained from cadavers [1].

Psychiatry related information on CAPS

However, the severity of PTSD symptoms as measured by the CAPS-1 score was significantly higher in women, nurses, and participants with <3 previous disaster duty experiences [2].

High impact information on CAPS

We also began the effort of differentiating true associated SNPs by selecting a small subset of significant SNPs (N = 26) and genotyped these in an independent sample of approximately 1,900 CAPS1 subjects [3].
Calcyphosine is an EF-hand Ca(2+)-binding protein, which was first isolated from the canine thyroid [4].
Calcyphosine-for calcium binding and regulated by cyclic AMP through phosphorylation protein-is a target of both the cyclic AMP and the Ca(+2)-phophatidylinositol cascades first isolated from dog thyroid, and then from rabbit and human brain [5].

Biological context of CAPS

Localization of human calcyphosine gene (CAPS) to the p13.3 region of chromosome 19 by in situ hybridization [6].
Calcyphosine, initially identified as thyroid protein p24, is a calcium-binding protein containing four EF-hand domains [7].
Using the canine calcyphosine cDNA sequence as a probe, we have isolated its human counterpart from a thyroid cDNA library [7].
Although the exact function of this 24kD protein is unknown, calcyphosine could be implicated in the cross-signaling between these cascades to coordinate cellular proliferation and differentiation [5].
The lack of expression of this murine pseudogene in brain and thyroid-two major sites of dog calcyphosine expression-was extended to 5 other rodents, and suggest the existence of alternative pathway(s) to fill the function of calcyphosine in rodents [5].

Analytical, diagnostic and therapeutic context of CAPS

Cloning and sequence analysis of human calcyphosine complementary DNA [7].
Northern blot analysis revealed that calcyphosine messenger RNA is much less abundant in human than in canine thyrocytes [7].
The stent rate was 1.3% with the hand-driven pump, 0.7% with CAPS 0.2 and 1.3% with CAPS 1 [8].

References

Longitudinal study on microleakage of three root-end filling materials by the fluid transport method and by capillary flow porometry. De Bruyne, M.A., De Bruyne, R.J., Rosiers, L., De Moor, R.J. International endodontic journal. (2005) [Pubmed]
Frequency of post-traumatic stress disorder among relief force workers after the tsunami in Asia: do rescuers become victims? Armagan, E., Engindeniz, Z., Devay, A.O., Erdur, B., Ozcakir, A. Prehospital and disaster medicine : the official journal of the National Association of EMS Physicians and the World Association for Emergency and Disaster Medicine in association with the Acute Care Foundation. (2006) [Pubmed]
A comprehensive association study for genes in inflammation pathway provides support for their roles in prostate cancer risk in the CAPS study. Zheng, S.L., Liu, W., Wiklund, F., Dimitrov, L., Bälter, K., Sun, J., Adami, H.O., Johansson, J.E., Sun, J., Chang, B., Loza, M., Turner, A.R., Bleecker, E.R., Meyers, D.A., Carpten, J.D., Duggan, D., Isaacs, W.B., Xu, J., Grönberg, H. Prostate (2006) [Pubmed]
Genomic structure of the sponge, Halichondria okadai calcyphosine gene. Yuasa, H.J., Nakatomi, A., Suzuki, T., Yazawa, M. Gene (2002) [Pubmed]
Loss of calcyphosine gene expression in mouse and other rodents. Clément, S., Dumont, J.E., Schurmans, S. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
Localization of human calcyphosine gene (CAPS) to the p13.3 region of chromosome 19 by in situ hybridization. Lefort, A., Passage, E., Libert, F., Szpirer, J., Vassart, G., Mattei, M.G. Cytogenet. Cell Genet. (1990) [Pubmed]
Cloning and sequence analysis of human calcyphosine complementary DNA. El Housni, H., Radulescu, A., Lecocq, R., Dumont, J.E., Christophe, D. Biochim. Biophys. Acta (1997) [Pubmed]
Controlled balloon inflation reduces long-term restenosis after percutaneous transluminal coronary angioplasty. Unverdorben, M., Glaeser, P., Degenhardt, R., Rippin, G., Berthold, H.K., Vallbracht, C. The Journal of invasive cardiology. (2001) [Pubmed]

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