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Gene Review:

DCL4 - dicer-like protein 4

Arabidopsis thaliana

Synonyms: ATDCL4, DICER-LIKE 4, F5O24.210, F5O24_210, dicer-like 4

Dunoyer, P. et al., Blevins, T. et al., Henderson, I.R. et al., Gasciolli, V. et al., Garcia, D. et al.

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Disease relevance of DCL4

In contrast, RNA virus infection is mainly affected by DCL4 [1].

High impact information on DCL4

DCL2, DCL3 and DCL4 showed functional redundancy in siRNA and tasiRNA production and in the establishment and maintenance of DNA methylation [2].
Five alleles defective in synthesis of 21-nt, but not 24-nt, siRNAs carry mutations in Dicer-like 4 (DCL4) that are involved in biogenesis of trans-acting siRNAs [3].
DICER-LIKE 4 is required for RNA interference and produces the 21-nucleotide small interfering RNA component of the plant cell-to-cell silencing signal [3].
RDR6 and DCL4 are required for systemic silencing, perhaps implicating ta-siRNA as a mobile signal [4].
Partially redundant functions of Arabidopsis DICER-like enzymes and a role for DCL4 in producing trans-acting siRNAs [5].

Biological context of DCL4

We show that the biogenesis and function of trans-acting siRNA can be genetically uncoupled from a bona fide DCL4-dependent pathway that accounts for RNA interference and for production of the 21-nt siRNA component of the plant cell-to-cell silencing signal [3].
While the four DCLs are partially redundant for CaLCuV-induced mRNA degradation, DCL4 in conjunction with RDR6 and HEN1 specifically facilitates extensive virus-induced silencing in new growth [1].

References

Four plant Dicers mediate viral small RNA biogenesis and DNA virus induced silencing. Blevins, T., Rajeswaran, R., Shivaprasad, P.V., Beknazariants, D., Si-Ammour, A., Park, H.S., Vazquez, F., Robertson, D., Meins, F., Hohn, T., Pooggin, M.M. Nucleic Acids Res. (2006) [Pubmed]
Dissecting Arabidopsis thaliana DICER function in small RNA processing, gene silencing and DNA methylation patterning. Henderson, I.R., Zhang, X., Lu, C., Johnson, L., Meyers, B.C., Green, P.J., Jacobsen, S.E. Nat. Genet. (2006) [Pubmed]
DICER-LIKE 4 is required for RNA interference and produces the 21-nucleotide small interfering RNA component of the plant cell-to-cell silencing signal. Dunoyer, P., Himber, C., Voinnet, O. Nat. Genet. (2005) [Pubmed]
Specification of leaf polarity in Arabidopsis via the trans-acting siRNA pathway. Garcia, D., Collier, S.A., Byrne, M.E., Martienssen, R.A. Curr. Biol. (2006) [Pubmed]
Partially redundant functions of Arabidopsis DICER-like enzymes and a role for DCL4 in producing trans-acting siRNAs. Gasciolli, V., Mallory, A.C., Bartel, D.P., Vaucheret, H. Curr. Biol. (2005) [Pubmed]

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