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Gene Review:

TCF7L1 - transcription factor 7-like 1 (T-cell...

Homo sapiens

Synonyms: HMG box transcription factor 3, TCF-3, TCF3, Transcription factor 7-like 1

Sagara, N. et al., Fitzpatrick, E. et al.

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Disease relevance of TCF7L1

The TCF-3 expression vector was transfected to gastric cancer cell line MKN28 to establish stable transformants [1].

High impact information on TCF7L1

Differential expression analyses of TCF genes in gastric cancer revealed that TCF-1 was expressed in most cases of primary gastric cancer at almost the same level as in normal gastric mucosa and that TCF-3 was occasionally up-regulated in primary gastric cancer [1].
Mitomycin C resistance induced by TCF-3 overexpression in gastric cancer cell line MKN28 is associated with DT-diaphorase down-regulation [1].
MMC resistance induced by TCF-3 overexpression is probably due to DTD down-regulation, which might provide a possible target for new therapy of drug-resistant gastric cancer [1].
Three independent MKN28 transformants overexpressing TCF-3 showed about 8-fold resistance to mitomycin C (MMC; IC50, 2.4 microg/ml) compared with MKN28 vector transfectants (IC50 = 0.3 microg/ml) [1].
DTD mRNA was also down-regulated in primary gastric cancer with TCF-3 up-regulation [1].

Biological context of TCF7L1

Maximum LOD scores were obtained for an SNP in TACR1 (LOD = 3.5) and for an SNP in TCF7L1 (LOD = 3.33), both achieving genome-wide significance [2].

References

Mitomycin C resistance induced by TCF-3 overexpression in gastric cancer cell line MKN28 is associated with DT-diaphorase down-regulation. Sagara, N., Katoh, M. Cancer Res. (2000) [Pubmed]
Fine mapping and SNP analysis of positional candidates at the preeclampsia susceptibility locus (PREG1) on chromosome 2. Fitzpatrick, E., Göring, H.H., Liu, H., Borg, A., Forrest, S., Cooper, D.W., Brennecke, S.P., Moses, E.K. Hum. Biol. (2004) [Pubmed]

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