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Gene Review

tcf7l1  -  transcription factor 7-like 1 (T-cell...

Xenopus (Silurana) tropicalis

Synonyms: XTCF-3, tcf-3, tcf3, tcf3c, tcf3d, ...
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High impact information on TGas083h23.1

  • We have determined that XIC, a Xenopus I-mfa domain protein that regulates Tcf3 binding, is required for dorsoaxial development and specifically for Siamois activity in establishing the dorsal organizer [1].
  • Finally, in UV-hyperventralized embryos, expression of endogenous Xtwn is confined to the vegetal pole and a Xtwn reporter gene is hyperinduced vegetally in a LEF1/TCF3-binding-site-dependent manner [2].
  • Repression through a distal TCF-3 binding site restricts Xenopus myf-5 expression in gastrula mesoderm [3].
  • These findings suggest that the forebrain/midbrain-specific gene XsalF negatively controls cellular responsiveness to posteriorizing Wnt signals by regulating region-specific GSK3beta and Tcf3 expression [4].


  1. XIC is required for Siamois activity and dorsoanterior development. Snider, L., Tapscott, S.J. Mol. Cell. Biol. (2005) [Pubmed]
  2. The Xenopus homeobox gene twin mediates Wnt induction of goosecoid in establishment of Spemann's organizer. Laurent, M.N., Blitz, I.L., Hashimoto, C., Rothbächer, U., Cho, K.W. Development (1997) [Pubmed]
  3. Repression through a distal TCF-3 binding site restricts Xenopus myf-5 expression in gastrula mesoderm. Yang, J., Mei, W., Otto, A., Xiao, L., Tao, Q., Geng, X., Rupp, R.A., Ding, X. Mech. Dev. (2002) [Pubmed]
  4. Xenopus XsalF: anterior neuroectodermal specification by attenuating cellular responsiveness to Wnt signaling. Onai, T., Sasai, N., Matsui, M., Sasai, Y. Dev. Cell (2004) [Pubmed]
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