High impact information on Rxrg

• In the myotome, however, RXRgamma is first expressed after myoblast differentiation, with RXRgamma transcripts being confined initially to its ventral region [1].
• This dynamic expression pattern of RXRgamma during myogenesis suggests its possible involvement in the differentiation of limb myoblasts but excludes a role in the differentiation of early myotomal myoblasts [1].
• Differential expression of the rat retinoid X receptor gamma gene during skeletal muscle differentiation suggests a role in myogenesis [1].
• The effect was enhanced by cotransfection of PPARgamma + retinoid X receptor gamma and prevented by MEK blockade [2].
• Retinoid X receptor-gamma (RXRgamma) is a transcription factor that mediates retinoid signalling and is expressed in rat heart during adult life [3].

Biological context of Rxrg

• First, in situ hybridization experiments were used to test for any spatio-temporal correlation between RXRgamma gene expression and the previously shown requirement for retinoid signalling in embryonic ventricular cardiomyocytes [3].

Anatomical context of Rxrg

• We show that the onset of RXRgamma expression coincides with the differentiation of limb myoblasts in vivo [1].

Associations of Rxrg with chemical compounds

• Even though previous studies have shown that transcripts encoding the murine retinoid X receptor gamma (RXRgamma) are present in skeletal muscle of mouse embryos and that cultured myoblasts are induced to differentiate upon retinoid treatment, a function for RXRgamma and retinoids in mammalian myogenesis has not yet been identified [1].
• Finally, this system was used to examine whether tRA and T3can influence levels of RXRgamma transcripts because they have been shown to have antagonistic effects in this system and to influence RXRgamma RNA levels in other systems [3].
• However, its expression in embryonic and neonatal heart has not been investigated and it is not known whether ventricular cardiomyocytes express RXRgamma or whether all- trans -retinoic acid (tRA) and thyroid hormone (T3) could influence RXRgamma transcript levels in these cells [3].

Analytical, diagnostic and therapeutic context of Rxrg

• It was shown by Northern blot experiments, that in this system, RXRgamma transcript levels are differentially influenced by these two hormones [3].

References