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Gene Review

RXRG  -  retinoid X receptor, gamma

Homo sapiens

Synonyms: NR2B3, Nuclear receptor subfamily 2 group B member 3, RXRC, Retinoic acid receptor RXR-gamma, Retinoid X receptor gamma
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Disease relevance of RXRG


High impact information on RXRG


Biological context of RXRG

  • In conclusion, in patients with RTH we have found two SNPs in the RXR-gamma gene; these SNPS are common in the general population, thus excluding a role for the RXR-gamma gene in these patients [8].
  • Analysis of all the 10 exons of the RXR-gamma gene, including intron-exon boundaries, promoter region and 3' untranslated region (UTR) reveled two variant bands in subjects II and III [8].
  • We infer that the DTM may be an important integrating center for photoperiodic control of seasonal physiology and suggest that the changes in retinoid X receptor gamma expression may be associated with seasonal changes in body weight and energy metabolism [2].
  • These data suggest that RXRgamma may contribute to disordered lipid metabolism in members of familial T2DM kindreds, but this gene is unlikely to explain the linkage of T2DM with this region [9].
  • RXRgamma haplotypes were also associated with several measures of pancreatic beta-cell function, consistent with the proposed role of lipid metabolism in insulin secretion [9].

Anatomical context of RXRG


Other interactions of RXRG

  • The aim of this study is to search for mutation within the RXR-gamma gene in unrelated subjects with diagnosed RTH without mutations in the TRbeta gene [8].


  1. High frequency of a retinoid X receptor gamma gene variant in familial combined hyperlipidemia that associates with atherogenic dyslipidemia. Nohara, A., Kawashiri, M.A., Claudel, T., Mizuno, M., Tsuchida, M., Takata, M., Katsuda, S., Miwa, K., Inazu, A., Kuipers, F., Kobayashi, J., Koizumi, J., Yamagishi, M., Mabuchi, H. Arterioscler. Thromb. Vasc. Biol. (2007) [Pubmed]
  2. Photoperiodic regulation of hypothalamic retinoid signaling: association of retinoid X receptor gamma with body weight. Ross, A.W., Webster, C.A., Mercer, J.G., Moar, K.M., Ebling, F.J., Schuhler, S., Barrett, P., Morgan, P.J. Endocrinology (2004) [Pubmed]
  3. Retinoid X receptor gamma mRNA expression is reduced in recurrent non-functioning pituitary adenomas. Gittoes, N.J., McCabe, C.J., Sheppard, M.C., Franklyn, J.A. Clin. Endocrinol. (Oxf) (1998) [Pubmed]
  4. Analysis of epistasis for diabetic nephropathy among type 2 diabetic patients. Hsieh, C.H., Liang, K.H., Hung, Y.J., Huang, L.C., Pei, D., Liao, Y.T., Kuo, S.W., Bey, M.S., Chen, J.L., Chen, E.Y. Hum. Mol. Genet. (2006) [Pubmed]
  5. Induction of apoptosis in primary meningioma cultures by fenretinide. Puduvalli, V.K., Li, J.T., Chen, L., McCutcheon, I.E. Cancer Res. (2005) [Pubmed]
  6. Cross-talk between signal transducer and activator of transcription (Stat5) and thyroid hormone receptor-beta 1 (TRbeta1) signaling pathways. Favre-Young, H., Dif, F., Roussille, F., Demeneix, B.A., Kelly, P.A., Edery, M., de Luze, A. Mol. Endocrinol. (2000) [Pubmed]
  7. Reduced expression of FOXC2 and brown adipogenic genes in human subjects with insulin resistance. Yang, X., Enerbäck, S., Smith, U. Obes. Res. (2003) [Pubmed]
  8. Search for genetic variants in the retinoid X receptor-gamma-gene by polymerase chain reaction-single-strand conformation polymorphism in patients with resistance to thyroid hormone without mutations in thyroid hormone receptor beta gene. Romeo, S., Menzaghi, C., Bruno, R., Sentinelli, F., Fallarino, M., Fioretti, F., Filetti, S., Balsamo, A., Di Mario, U., Baroni, M.G. Thyroid (2004) [Pubmed]
  9. Mutation screening and association of human retinoid X receptor gamma variation with lipid levels in familial type 2 diabetes. Wang, H., Chu, W., Hemphill, C., Hasstedt, S.J., Elbein, S.C. Mol. Genet. Metab. (2002) [Pubmed]
  10. Retinoid X receptor-gamma and peroxisome proliferator-activated receptor-gamma expression predicts thyroid carcinoma cell response to retinoid and thiazolidinedione treatment. Klopper, J.P., Hays, W.R., Sharma, V., Baumbusch, M.A., Hershman, J.M., Haugen, B.R. Mol. Cancer Ther. (2004) [Pubmed]
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