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Gene Review

ALP  -  thiol protease aleurain

Arabidopsis thaliana

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High impact information on AALP

  • Further, we found that AtELP interacts in a similar manner with the NTPP of the endogenous vacuolar protein AtALEU (Arabidopsis thaliana Aleu), a protein highly homologous to barley aleurain [1].
  • The mRNA levels of both alphaVPE and gammaVPE were increased in the primary leaves during senescence in parallel with the increase of the mRNA level of a senescence-associated gene (SAG2) [2].
  • Analysis by surface plasmon resonance showed that the lumenal domain of PV72 bound to an NPIR (a typical vacuolar targeting signal)-containing peptide of the precursor of a cysteine proteinase, AtALEU, in the presence of Ca(2+) (K(D) = 0.1 micro M) [3].
  • The AtALEU precursor might be trapped by PV72-HDEL in the ER and not transported to the vacuoles [3].


  1. The plant vacuolar sorting receptor AtELP is involved in transport of NH(2)-terminal propeptide-containing vacuolar proteins in Arabidopsis thaliana. Ahmed, S.U., Rojo, E., Kovaleva, V., Venkataraman, S., Dombrowski, J.E., Matsuoka, K., Raikhel, N.V. J. Cell Biol. (2000) [Pubmed]
  2. Vacuolar processing enzyme is up-regulated in the lytic vacuoles of vegetative tissues during senescence and under various stressed conditions. Kinoshita, T., Yamada, K., Hiraiwa, N., Kondo, M., Nishimura, M., Hara-Nishimura, I. Plant J. (1999) [Pubmed]
  3. An ER-localized form of PV72, a seed-specific vacuolar sorting receptor, interferes the transport of an NPIR-containing proteinase in Arabidopsis leaves. Watanabe, E., Shimada, T., Tamura, K., Matsushima, R., Koumoto, Y., Nishimura, M., Hara-Nishimura, I. Plant Cell Physiol. (2004) [Pubmed]
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