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Gene Review

Ctsh  -  cathepsin H

Mus musculus

Synonyms: AL022844, Cat H, Cathepsin B3, Cathepsin BA, Pro-cathepsin H
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Disease relevance of Ctsh

  • Cathepsin H and beta-glucuronidase activities were not localized in the plasma membrane fractions of the B16 melanomas [1].
  • The mean cathepsin H level was significantly higher for both groups of patients compared to normal sera level, being highest for metastatic melanoma patients [2].

High impact information on Ctsh


Anatomical context of Ctsh


Associations of Ctsh with chemical compounds

  • We have isolated a cDNA clone for cathepsin H, a lysosomal cysteine proteinase from a cDNA subtraction library of mouse macrophage genes induced by IFN-gamma, and have characterized its expression [7].

Other interactions of Ctsh


  1. Cathepsin B: association with plasma membrane in metastatic tumors. Sloane, B.F., Rozhin, J., Johnson, K., Taylor, H., Crissman, J.D., Honn, K.V. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  2. Enzyme-linked immunosorbent assay for the detection of total cathepsin H in human tissue cytosols and sera. Schweiger, A., Stabuc, B., Popovíc, T., Turk, V., Kos, J. J. Immunol. Methods (1997) [Pubmed]
  3. Close relationship of the major excreted protein of transformed murine fibroblasts to thiol-dependent cathepsins. Denhardt, D.T., Hamilton, R.T., Parfett, C.L., Edwards, D.R., St Pierre, R., Waterhouse, P., Nilsen-Hamilton, M. Cancer Res. (1986) [Pubmed]
  4. Cathepsin B Is Inhibited in Mutant Cells Selected during Persistent Reovirus Infection. Ebert, D.H., Kopecky-Bromberg, S.A., Dermody, T.S. J. Biol. Chem. (2004) [Pubmed]
  5. Lysosomal enzyme trafficking between phagosomes, endosomes, and lysosomes in J774 macrophages. Enrichment of cathepsin H in early endosomes. Claus, V., Jahraus, A., Tjelle, T., Berg, T., Kirschke, H., Faulstich, H., Griffiths, G. J. Biol. Chem. (1998) [Pubmed]
  6. Cloning and characterization of a mouse cysteine proteinase. Portnoy, D.A., Erickson, A.H., Kochan, J., Ravetch, J.V., Unkeless, J.C. J. Biol. Chem. (1986) [Pubmed]
  7. IFN-gamma increases cathepsin H mRNA levels in mouse macrophages. Lafuse, W.P., Brown, D., Castle, L., Zwilling, B.S. J. Leukoc. Biol. (1995) [Pubmed]
  8. Differential expression patterns of cathepsins B, H, K, L and S in the mouse ovary. Oksjoki, S., Söderström, M., Vuorio, E., Anttila, L. Mol. Hum. Reprod. (2001) [Pubmed]
  9. Murine M cells express annexin V specifically. Verbrugghe, P., Waelput, W., Dieriks, B., Waeytens, A., Vandesompele, J., Cuvelier, C.A. J. Pathol. (2006) [Pubmed]
  10. The structure of the mouse cathepsin B gene and its putative promoter. Qian, F., Frankfater, A., Chan, S.J., Steiner, D.F. DNA Cell Biol. (1991) [Pubmed]
  11. Effect of Tri-O-cresyl phosphate (TOCP) on proteolytic enzyme activities in mouse liver in vivo. Saleem, M.A., Williams, F.M., Wilkins, R.M., Shakoori, A.R., Mantle, D. J. Environ. Pathol. Toxicol. Oncol. (1998) [Pubmed]
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