The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Ctsh  -  cathepsin H

Mus musculus

Synonyms: AL022844, Cat H, Cathepsin B3, Cathepsin BA, Pro-cathepsin H
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Ctsh

  • Cathepsin H and beta-glucuronidase activities were not localized in the plasma membrane fractions of the B16 melanomas [1].
  • The mean cathepsin H level was significantly higher for both groups of patients compared to normal sera level, being highest for metastatic melanoma patients [2].
 

High impact information on Ctsh

 

Anatomical context of Ctsh

 

Associations of Ctsh with chemical compounds

  • We have isolated a cDNA clone for cathepsin H, a lysosomal cysteine proteinase from a cDNA subtraction library of mouse macrophage genes induced by IFN-gamma, and have characterized its expression [7].
 

Other interactions of Ctsh

References

  1. Cathepsin B: association with plasma membrane in metastatic tumors. Sloane, B.F., Rozhin, J., Johnson, K., Taylor, H., Crissman, J.D., Honn, K.V. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  2. Enzyme-linked immunosorbent assay for the detection of total cathepsin H in human tissue cytosols and sera. Schweiger, A., Stabuc, B., Popovíc, T., Turk, V., Kos, J. J. Immunol. Methods (1997) [Pubmed]
  3. Close relationship of the major excreted protein of transformed murine fibroblasts to thiol-dependent cathepsins. Denhardt, D.T., Hamilton, R.T., Parfett, C.L., Edwards, D.R., St Pierre, R., Waterhouse, P., Nilsen-Hamilton, M. Cancer Res. (1986) [Pubmed]
  4. Cathepsin B Is Inhibited in Mutant Cells Selected during Persistent Reovirus Infection. Ebert, D.H., Kopecky-Bromberg, S.A., Dermody, T.S. J. Biol. Chem. (2004) [Pubmed]
  5. Lysosomal enzyme trafficking between phagosomes, endosomes, and lysosomes in J774 macrophages. Enrichment of cathepsin H in early endosomes. Claus, V., Jahraus, A., Tjelle, T., Berg, T., Kirschke, H., Faulstich, H., Griffiths, G. J. Biol. Chem. (1998) [Pubmed]
  6. Cloning and characterization of a mouse cysteine proteinase. Portnoy, D.A., Erickson, A.H., Kochan, J., Ravetch, J.V., Unkeless, J.C. J. Biol. Chem. (1986) [Pubmed]
  7. IFN-gamma increases cathepsin H mRNA levels in mouse macrophages. Lafuse, W.P., Brown, D., Castle, L., Zwilling, B.S. J. Leukoc. Biol. (1995) [Pubmed]
  8. Differential expression patterns of cathepsins B, H, K, L and S in the mouse ovary. Oksjoki, S., Söderström, M., Vuorio, E., Anttila, L. Mol. Hum. Reprod. (2001) [Pubmed]
  9. Murine M cells express annexin V specifically. Verbrugghe, P., Waelput, W., Dieriks, B., Waeytens, A., Vandesompele, J., Cuvelier, C.A. J. Pathol. (2006) [Pubmed]
  10. The structure of the mouse cathepsin B gene and its putative promoter. Qian, F., Frankfater, A., Chan, S.J., Steiner, D.F. DNA Cell Biol. (1991) [Pubmed]
  11. Effect of Tri-O-cresyl phosphate (TOCP) on proteolytic enzyme activities in mouse liver in vivo. Saleem, M.A., Williams, F.M., Wilkins, R.M., Shakoori, A.R., Mantle, D. J. Environ. Pathol. Toxicol. Oncol. (1998) [Pubmed]
 
WikiGenes - Universities