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Gene Review

SETDB2  -  SET domain, bifurcated 2

Homo sapiens

Synonyms: C13orf4, CLLD8, CLLL8, Chronic lymphocytic leukemia deletion region gene 8 protein, Histone-lysine N-methyltransferase SETDB2, ...
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Disease relevance of SETDB2


High impact information on SETDB2


Biological context of SETDB2

  • The functional domains present within CLLD7 and CLLD8 suggest that the proteins may be involved in critical cellular processes such as cell cycle and transcriptional control and could therefore be directly or indirectly involved in leukemogenesis [2].

Anatomical context of SETDB2

  • Although the precise functions of SETDB2 and PHF11 are not known, both proteins are expressed in cells of the immune system and include conserved domains that suggest a role in chromatin remodelling or transcriptional regulation, respectively [1].


  1. Polymorphisms within the PHF11 gene at chromosome 13q14 are associated with childhood atopic dermatitis. Jang, N., Stewart, G., Jones, G. Genes Immun. (2005) [Pubmed]
  2. Cloning and characterization of CLLD6, CLLD7, and CLLD8, novel candidate genes for leukemogenesis at chromosome 13q14, a region commonly deleted in B-cell chronic lymphocytic leukemia. Mabuchi, H., Fujii, H., Calin, G., Alder, H., Negrini, M., Rassenti, L., Kipps, T.J., Bullrich, F., Croce, C.M. Cancer Res. (2001) [Pubmed]
  3. SU(VAR)3-9 is a conserved key function in heterochromatic gene silencing. Schotta, G., Ebert, A., Reuter, G. Genetica (2003) [Pubmed]
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