Disease relevance of RCBTB1

• Cloning and characterization of CLLD6, CLLD7, and CLLD8, novel candidate genes for leukemogenesis at chromosome 13q14, a region commonly deleted in B-cell chronic lymphocytic leukemia [1].
• To study the possible response of peripheral neurons, we cultured chicken dorsal root ganglion neurons from different developmental stages from embryonic day 4.5 (E4.5; St 25) to E9 (St 35) on recombinant HB-GAM [2].

High impact information on RCBTB1

• No acf(-)(/)(-) blastocysts were detectable following implantation at E4.5, and isolated acf(-)(/)(-) blastocysts failed to proliferate in vitro [3].
• In these genes, paternal silencing and differential histone marks arise during differentiation of the trophoblast lineage between E4.5 and E7 [4].
• Three novel genes, CLLD6, CLLD7, and CLLD8, were isolated and characterized [1].
• CLLD7 has both an RCC1 and a BTB domain, and could thus be involved in cell cycle regulation by chromatin remodeling [1].
• In chicken embryos sensory afferents reach the spinal cord at stage 25 (E4.5) but do not arborize within the gray matter until stage 30 [5].

Chemical compound and disease context of RCBTB1

• 13q deletion in chronic lymphocytic leukemia: characterization of E4.5, a novel chromosome condensation regulator-like guanine nucleotide exchange factor [6].

Biological context of RCBTB1

• The functional domains present within CLLD7 and CLLD8 suggest that the proteins may be involved in critical cellular processes such as cell cycle and transcriptional control and could therefore be directly or indirectly involved in leukemogenesis [1].
• E4.5 gene encodes for a 4 kb mRNA expressed in various tissues and has an open reading frame of 531 amino acids [6].

Anatomical context of RCBTB1

• Semaphorin3A bead implantations into E4.5 forelimbs caused failure of nerves and blood vessels to form and to deviate away from the bead [7].
• Between embryonic Days 6.5 and 16 (E6.5 and E16), a single 3-kb ctrkA transcript is detected in sympathetic and sensory ganglia, and in situ hybridization experiments reveal the presence of ctrkA mRNA in both ganglia from E4.5 onward [8].
• A small number of cells appeared in the vagus nerve trunks at E4.5 and that number increased at E7.5-8 [9].
• 5. This Nerve extended to the yolk stalk at E4.5 and to duodenum at E6 [9].
• 5. At E4.5, expression switches to the gonad of both sexes and then localizes to the gonadal cortex [10].

Analytical, diagnostic and therapeutic context of RCBTB1

• The contributions of GFP-positive cells to different tissues of 4n<-->2n chimeric blastocysts labelled with tauGFP were analysed at E3.5 and E4.5 using confocal microscopy [11].

References