Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

KLF16 - Kruppel-like factor 16

Homo sapiens

Synonyms: BTE-binding protein 4, BTEB4, Basic transcription element-binding protein 4, DRRF, Krueppel-like factor 16, ...

Hwang, C.K. et al., Kaczynski, J.A. et al.

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High impact information on KLF16

Consequently, DRRF can modulate the activity of these dopamine receptor promoters [1].
Dopamine receptor regulating factor, DRRF: a zinc finger transcription factor [1].
Mice treated with drugs that increase extracellular striatal dopamine levels (cocaine), block dopamine receptors (haloperidol), or destroy dopamine terminals (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) show significant alterations in DRRF mRNA [1].
Highest DRRF mRNA levels are found in brain with a specific regional distribution including olfactory bulb and tubercle, nucleus accumbens, striatum, hippocampus, amygdala, and frontal cortex [1].
Similarly to the recently described BTEB3, we demonstrate that the N-terminal region of BTEB4 directly represses transcription and binds the co-repressor mSin3A [2].

Regulatory relationships of KLF16

Also, we show that both BTEB3 and BTEB4 repress the CYP1A1 gene promoter via the BTE site in HepG2 and BxPC3 cells [2].

References

Dopamine receptor regulating factor, DRRF: a zinc finger transcription factor. Hwang, C.K., D'Souza, U.M., Eisch, A.J., Yajima, S., Lammers, C.H., Yang, Y., Lee, S.H., Kim, Y.M., Nestler, E.J., Mouradian, M.M. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
Functional analysis of basic transcription element (BTE)-binding protein (BTEB) 3 and BTEB4, a novel Sp1-like protein, reveals a subfamily of transcriptional repressors for the BTE site of the cytochrome P4501A1 gene promoter. Kaczynski, J.A., Conley, A.A., Fernandez Zapico, M., Delgado, S.M., Zhang, J.S., Urrutia, R. Biochem. J. (2002) [Pubmed]

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