The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

SMT2  -  24-methylenesterol C-methyltransferase 2

Arabidopsis thaliana

Synonyms: COTYLEDON VASCULAR PATTERN 1, CVP1, F14O10.7, F14O10_7, FRILL1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on SMT2

  • We identified CVP1 and found that it encodes STEROL METHYLTRANSFERASE2 (SMT2), an enzyme in the sterol biosynthetic pathway [1].
  • In the Arabidopsis cotyledon vascular pattern1 (cvp1) mutant, vascular cells are not arranged in parallel files and are misshapen, suggesting that CVP1 has a role in promoting vascular cell polarity and alignment [1].
  • Neither cvp1 nor cvp2 mutants displayed altered auxin perception, biosynthesis, or transport, suggesting that auxin metabolism is not generally affected in these mutants [2].
  • Observations of the early petal development revealed that the morphology of the developing frl1 petal was normal until the middle of stage 9, but the frl1 phenotype became apparent in stages later than 10 [3].
  • These observations indicate that the frl1 mutation affects the number of cell divisions and the subsequent cell expansion during the late stage of petal lamina formation, and that FRL1 might be maintaining the mitotic state or suppressing the transition to the endo-reduplication cycle [3].

Biological context of SMT2

  • The general phenotype of transformants was similar to that of controls, although SMT2 transformants displayed a reduced height at anthesis [4].
  • The results suggest plant SMT2 has a position-specific substrate specificity for Delta(24(25))-sterols and contains a single active center to catalyze the consecutive C(1)-transfer activities by substrate reaction channels similar to the fungal SMT1 [5].

Associations of SMT2 with chemical compounds


  1. The identification of CVP1 reveals a role for sterols in vascular patterning. Carland, F.M., Fujioka, S., Takatsuto, S., Yoshida, S., Nelson, T. Plant Cell (2002) [Pubmed]
  2. Genetic regulation of vascular tissue patterning in Arabidopsis. Carland, F.M., Berg, B.L., FitzGerald, J.N., Jinamornphongs, S., Nelson, T., Keith, B. Plant Cell (1999) [Pubmed]
  3. FRL1 is required for petal and sepal development in Arabidopsis. Hase, Y., Tanaka, A., Baba, T., Watanabe, H. Plant J. (2000) [Pubmed]
  4. Sterol composition and growth of transgenic tobacco plants expressing type-1 and type-2 sterol methyltransferases. Sitbon, F., Jonsson, L. Planta (2001) [Pubmed]
  5. Sterol methyltransferase2: purification, properties, and inhibition. Zhou, W., Nes, W.D. Arch. Biochem. Biophys. (2003) [Pubmed]
WikiGenes - Universities