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Gene Review

SMT1  -  cycloartenol-c-24-methyltransferase

Arabidopsis thaliana

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Disease relevance of SMT1


High impact information on SMT1


Biological context of SMT1


Anatomical context of SMT1


Associations of SMT1 with chemical compounds


Enzymatic interactions of SMT1

  • The results suggest plant SMT2 has a position-specific substrate specificity for Delta(24(25))-sterols and contains a single active center to catalyze the consecutive C(1)-transfer activities by substrate reaction channels similar to the fungal SMT1 [8].


  1. Sterol methyltransferase 1 controls the level of cholesterol in plants. Diener, A.C., Li, H., Zhou, W., Whoriskey, W.J., Nes, W.D., Fink, G.R. Plant Cell (2000) [Pubmed]
  2. Plant development: A role for sterols in embryogenesis. Clouse, S.D. Curr. Biol. (2000) [Pubmed]
  3. Novel biosynthetic pathway of castasterone from cholesterol in tomato. Kim, T.W., Chang, S.C., Lee, J.S., Takatsuto, S., Yokota, T., Kim, S.K. Plant Physiol. (2004) [Pubmed]
  4. Transformation of Saccharomyces cerevisiae with a cDNA encoding a sterol C-methyltransferase from Arabidopsis thaliana results in the synthesis of 24-ethyl sterols. Husselstein, T., Gachotte, D., Desprez, T., Bard, M., Benveniste, P. FEBS Lett. (1996) [Pubmed]
  5. Identification of cDNAs encoding sterol methyl-transferases involved in the second methylation step of plant sterol biosynthesis. Bouvier-Navé, P., Husselstein, T., Desprez, T., Benveniste, P. Eur. J. Biochem. (1997) [Pubmed]
  6. Sterol composition and growth of transgenic tobacco plants expressing type-1 and type-2 sterol methyltransferases. Sitbon, F., Jonsson, L. Planta (2001) [Pubmed]
  7. The ratio of campesterol to sitosterol that modulates growth in Arabidopsis is controlled by STEROL METHYLTRANSFERASE 2;1. Schaeffer, A., Bronner, R., Benveniste, P., Schaller, H. Plant J. (2001) [Pubmed]
  8. Sterol methyltransferase2: purification, properties, and inhibition. Zhou, W., Nes, W.D. Arch. Biochem. Biophys. (2003) [Pubmed]
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