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Gene Review:

CRC - putative transcription factor CRABS CLAW

Arabidopsis thaliana

Synonyms: CRABS CLAW, F4N2.14, F4N2_14, TRANSCRIPTION FACTOR CRC

Lee, J.Y. et al., Meister, R.J. et al., Fourquin, C. et al., Yamaguchi, T. et al.

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Disease relevance of CRC

Roles of individual regions of CRC and INO in these effects were assessed using chimeric proteins with PRO(INO) and PRO(CRC) and the relatively constitutive cauliflower mosaic virus PRO(35S) [1].

High impact information on CRC

CRABS CLAW (CRC), a member of the YABBY gene family, is required for nectary and carpel development [2].
Within the conserved modules, we identified putative binding sites of LEAFY and MADS box proteins, and functional in vivo analyses revealed their importance for CRC expression [2].
Phylogenetic footprinting efficiently identified functionally important regulatory regions (modules), indicating that CRC expression is regulated by a combination of positive and negative regulatory elements in the modules [2].
CRABS CLAW (CRC) and TOUSLED (TSL) control important aspects of carpel development in the model plant, Arabidopsis thaliana [3].
When combined with INO sequences, the central and carboxyl-terminal regions of CRC were individually sufficient to overcome inhibitory effects of SUPERMAN within the outer integument [1].

Other interactions of CRC

We have identified putative orthologues of CRC and TSL from A. trichopoda and C. aquatica, respectively [3].

Analytical, diagnostic and therapeutic context of CRC

Molecular cloning reveals that DL is a member of the YABBY gene family and is closely related to the CRABS CLAW (CRC) gene of Arabidopsis thaliana [4].

References

Multiple protein regions contribute to differential activities of YABBY proteins in reproductive development. Meister, R.J., Oldenhof, H., Bowman, J.L., Gasser, C.S. Plant Physiol. (2005) [Pubmed]
Activation of CRABS CLAW in the Nectaries and Carpels of Arabidopsis. Lee, J.Y., Baum, S.F., Alvarez, J., Patel, A., Chitwood, D.H., Bowman, J.L. Plant Cell (2005) [Pubmed]
Evidence that CRABS CLAW and TOUSLED have conserved their roles in carpel development since the ancestor of the extant angiosperms. Fourquin, C., Vinauger-Douard, M., Fogliani, B., Dumas, C., Scutt, C.P. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
The YABBY gene DROOPING LEAF regulates carpel specification and midrib development in Oryza sativa. Yamaguchi, T., Nagasawa, N., Kawasaki, S., Matsuoka, M., Nagato, Y., Hirano, H.Y. Plant Cell (2004) [Pubmed]

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